Total study population (n = 260,151) | Screening-recruited cohorts (n = 24,727) | Other centers (n = 235,424) | |||||||
---|---|---|---|---|---|---|---|---|---|
N cases/non-cases | Model 1 | Model 2 | N cases/non-cases | Model 1 | Model 2 | N cases/non-cases | Model 1 | Model 2 | |
HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | ||||
WCRF/AICR lifestyle score, continuous (0–8) | 1277/258,874 | 0.97 (0.92–1.02) | 0.98 (0.93–1.03) | 159/24,568 | 0.83 (0.72–0.97) | 0.85 (0.73–0.99) | 1118/234,306 | 0.99 (0.93–1.05) | 0.99 (0.94–1.05) |
WCRF/AICR lifestyle score 0–3 | 125/26,684 | Ref. | Ref. | 20/2426 | Ref. | Ref. | 105/24,258 | Ref. | Ref. |
WCRF/AICR lifestyle score > 3–5 | 811/157,392 | 1.11 (0.92–1.34) | 1.12 (0.93–1.36) | 104/14,910 | 0.81 (0.50–1.31) | 0.84 (0.52–1.36) | 707/142,482 | 1.16 (0.95–1.43) | 1.17 (0.95–1.45) |
WCRF/AICR lifestyle score > 5 | 341/74,798 | 0.96 (0.78–1.18) | 0.98 (0.80–1.22) | 35/7232 | 0.56 (0.32–0.97) | 0.59 (0.33–1.03) | 306/67,566 | 1.04 (0.83–1.30) | 1.06 (0.84–1.33) |
Education level | |||||||||
None/primary school | 262/79,542 | 0.91 (0.80–1.02) | 0.91 (0.80–1.03) | 49/7664 | 0.74 (0.56–0.97) | 0.76 (0.58–1.00) | 213/71,878 | 0.95 (0.83–1.09) | 0.95 (0.83–1.09) |
Technical/secondary school | 596/113,801 | 0.97 (0.90–1.05) | 0.99 (0.91–1.07) | 79/12,825 | 0.86 (0.69–1.06) | 0.87 (0.70–1.08) | 517/100,976 | 0.98 (0.91–1.07) | 1.00 (0.92–1.09) |
University degree | 419/65,531 | 1.00 (0.91–1.09) | 1.00 (0.91–1.10) | 31/4079 | 0.93 (0.66–1.31) | 0.95 (0.67–1.35) | 388/61,452 | 1.00 (0.91–1.10) | 1.01 (0.91–1.11) |
Smoking status | |||||||||
Never smokers | 799/155,775 | 0.99 (0.93–1.06) | 1.00 (0.93–1.07) | 75/11,065 | 0.85 (0.68–1.07) | 0.85 (0.68–1.06) | 724/144,710 | 1.01 (0.94–1.08) | 1.01 (0.94–1.09) |
Ever smokers | 478/103,099 | 0.95 (0.87–1.03) | 0.96 (0.88–1.05) | 84/13,503 | 0.81 (0.66–0.99) | 0.84 (0.68–1.03) | 394/89,596 | 0.98 (0.89–1.07) | 0.99 (0.90–1.09) |
Menopausal status at recruitment | |||||||||
Premenopausal | 374/86,383 | 1.05 (0.95–1.15) | 1.04 (0.95–1.15) | 28/4321 | 0.90 (0.63–1.28) | 0.88 (0.61–1.26) | 346/82,062 | 1.06 (0.96–1.17) | 1.06 (0.95–1.17) |
Postmenopausal | 599/129,150 | 0.94 (0.87–1.01) | 0.94 (0.87–1.02) | 95/15,964 | 0.86 (0.70–1.04) | 0.86 (0.71–1.05) | 504/113,186 | 0.95 (0.87–1.03) | 0.96 (0.88–1.04) |
Perimenopausal | 304/43,341 | 0.95 (0.86–1.06) | 0.97 (0.87–1.08) | 36/4283 | 0.78 (0.57–1.06) | 0.83 (0.60–1.14) | 268/39,058 | 0.98 (0.87–1.10) | 1.00 (0.89–1.12) |