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Table 3 Summary of the causal effects of T2D and T2D-related glycemic/anthropometric traits on ALS with various MR methods

From: Causal association of type 2 diabetes with amyotrophic lateral sclerosis: new evidence from Mendelian randomization using GWAS summary statistics

Exposures (unit)Random-effects IVWWeighted medianMR-Egger
Odds ratioIntercept (p value)
T2D0.93 (0.87–1.00)0.94 (0.86–1.03)0.90 (0.72–1.14)0.002 (0.786)
BMI (4.8 kg/m2)1.00 (0.87–1.16)0.93 (0.77–1.13)0.80 (0.56–1.15)0.007 (0.170)
Fasting glucose (mmol/L)1.09 (0.90–1.31)1.08 (0.98–1.43)1.10 (0.97–1.57)0.001 (0.852)
Fasting insulin (pmol/L)0.78 (0.49–1.24)0.66 (0.33–1.31)1.91 (0.06–61.7)−0.015 (0.615)
HbA1c (%)0.97 (0.67–1.39)0.85 (0.55–1.32)0.95 (0.47–1.91)0.001 (0.875)