Table 3 Summary of the causal effects of T2D and T2D-related glycemic/anthropometric traits on ALS with various MR methods
Exposures (unit) | Random-effects IVW | Weighted median | MR-Egger | |
|---|---|---|---|---|
Odds ratio | Intercept (p value) | |||
T2D | 0.93 (0.87–1.00) | 0.94 (0.86–1.03) | 0.90 (0.72–1.14) | 0.002 (0.786) |
BMI (4.8 kg/m2) | 1.00 (0.87–1.16) | 0.93 (0.77–1.13) | 0.80 (0.56–1.15) | 0.007 (0.170) |
Fasting glucose (mmol/L) | 1.09 (0.90–1.31) | 1.08 (0.98–1.43) | 1.10 (0.97–1.57) | 0.001 (0.852) |
Fasting insulin (pmol/L) | 0.78 (0.49–1.24) | 0.66 (0.33–1.31) | 1.91 (0.06–61.7) | −0.015 (0.615) |
HbA1c (%) | 0.97 (0.67–1.39) | 0.85 (0.55–1.32) | 0.95 (0.47–1.91) | 0.001 (0.875) |