Introduction of primary screening using high-risk HPV DNA detection in the Dutch cervical cancer screening programme: a population-based cohort study

Table 2 Number of positive screen tests and number of referrals per detected CIN2+ or CIN3+ lesion

		Cytology	HPV	Difference per round (%)
Positive screens
Total*
Number of positives needed to detect one	CIN2+	4.4	6.3	44
Number of positives needed to detect one	CIN3+	7.2	10.8	50
Referrals
Total*
Number of referrals needed to detect one	CIN2+	1.9	2.7	47
Number of referrals needed to detect one	CIN3+	3.0	4.6	53
HSIL
Number of referrals needed to detect one	CIN2+	1.3	1.3	−2
Number of referrals needed to detect one	CIN3+	1.8	1.8	−2
ASC-US/LSIL
Number of referrals needed to detect one	CIN2+	3.0	4.7	57
Number of referrals needed to detect one	CIN3+	7.5	12.0	60

N.B. Triage algorithms for ASC-US/LSIL screens differ between the cytology-based and hrHPV-based programmes; in the hrHPV-based programme, all hrHPV-positive, ASC-US/LSIL screens are directly referred, whereas in the cytology-based programme, ASC-US/LSIL screens were triaged for repeat cytology after 6 months
*Total includes all positive hrHPV tests irrespective of the reflex cytology result (includes hrHPV-positive screens with reflex cytology of NILM, inadequate or missing)

ISSN: 1741-7015