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Fig. 8 | BMC Medicine

Fig. 8

From: Identifying potential causal effects of age at menarche: a Mendelian randomization phenome-wide association study

Fig. 8

Estimates of the potential causal effect of age at menarche on neuroticism. BMI, body mass index; CI, confidence interval; GPC, Genetics of Personality Consortium; UKBB, UK Biobank. The estimates reflect the change in the harmonized neuroticism score per year decrease in age at menarche adjusted for age and principal components. The Genetics of Personality Consortium (GPC) analysis included 63,661 individuals. For the GPC consortium, the main analysis included 344 SNPs in the genetic risk score for age at menarche, while the sensitivity analysis excluding SNPs associated with BMI included 208 SNPs

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BMC Medicine

ISSN: 1741-7015

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