Analysis | Incremental mean costs, £ (95% CI)a, b, c | Incremental mean QALYs/outcomes (95% CI)a, b, c | Mean incremental cost-effectiveness ratio (£/QALY/outcome) |
---|---|---|---|
Complete cases over 12-month follow-up (n = 176) | 563.74 (88.18 to 1154.18) | −0.047 (− 0.078 to − 0.015) | Dominated |
 Sensitivity analysis: lower sodium bicarbonate costd | 352.76 (− 154.37 to 957.45) | − 0.047 (− 0.078 to − 0.015) | Dominated |
 Sensitivity analysis: lower inpatient stay coste | 539.03 (109.13 to 1050.45) | − 0.046 (− 0.078 to − 0.015) | Dominated |
 Sensitivity analysis: using ICECAP valuef | 636.20 (187.59 to 1189.24) | − 0.017 (− 0.032 to 0.0001) | Dominated |
 Sensitivity analysis: using life satisfaction valueg | 580.19 (143.38 to 1130.11) | − 0.396 (− 0.733 to − 0.059) | Dominated |
Complete cases over 24-month follow-up (n = 114)h | 591.00 (166.29 to 1078.36) | − 0.083 (− 0.166 to − 0.005) | Dominated |
 Sensitivity analysis: lower sodium bicarbonate costd | 242.59 (− 179.63 to 720.27) | − 0.083 (− 0.166 to − 0.005) | Dominated |
 Sensitivity analysis: lower inpatient stay coste | 593.74 (191.37 to 1072.07) | − 0.083 (− 0.166 to − 0.005) | Dominated |
 Sensitivity analysis: using ICECAP valuef | 598.87 (215.69 to 1052.43) | −0.051 (− 0.095 to − 0.010) | Dominated |
 Sensitivity analysis: using life satisfaction valueg | 682.44 (257.28 to 1142.63) | − 0.974 (− 1.762 to − 0.190) | Dominated |
Complete cases over 24-month follow-up and all participants starting renal replacement therapy during the trial (n = 161)h | 808.93 (− 4124.71 to 5411.89) | − 0.074 (− 0.151 to − 0.003) | Dominated |
 Sensitivity analysis: lower sodium bicarbonate costd | 534.61 (− 4385.90 to 5149.69) | − 0.074 (− 0.150 to − 0.003) | Dominated |
 Sensitivity analysis: lower inpatient stay coste | 817.21 (− 4097.90 to 5415.22) | − 0.073 (− 0.151 to − 0.001) | Dominated |
 Sensitivity analysis: using ICECAP valuef, i | 422.08 (− 4091.74 to 4629.60) | − 0.046 (− 0.090 to − 0.002) | Dominated |
 Sensitivity analysis: lower dialysis costj | 600.26 (− 3560.78 to 4379.06) | − 0.075 (− 0.154 to − 0.001) | Dominated |
 Sensitivity analysis: higher dialysis costk | 899.41 (− 4327.11 to 5714.04) | − 0.074 (− 0.156 to 0.002) | Dominated |
 Sensitivity analysis: using life satisfaction valueg, l | 928.18 (− 4373.23 to 5729.68) | − 0.072 (− 1.366 to 0.002) | Dominated |