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Table 3 Diagnostic test statistics of the study cohort showing the accuracy and missed cancer rates for each phi threshold as a triage test pre-MRI and biopsy. PSAd thresholds are shown as a comparator though this metric is not usually available before an mpMRI. Detection rates for cancer are shown using definitions of ≥ Grade Group 2 (GG2) or ≥ Cambridge Prognostic Group 3 [CPG3]. (*percentage out of 258 cancers detected, ** percentage out of 176 cancers detected)

From: Clinical utility and cost modelling of the phi test to triage referrals into image-based diagnostic services for suspected prostate cancer: the PRIM (Phi to RefIne Mri) study

 

≥ GG2 cancer detection

≥ CPG3 cancer detection

Threshold

Sensitivity

Specificity

NPV

% cancers missed*

Sensitivity

Specificity

NPV

% cancers missed**

phi

20

0.99

0.10

0.90

1.1

1.00

0.08

1.00

0

25

0.96

0.25

0.87

4.2

0.99

0.22

0.99

0.05

30

0.92

0.40

0.85

7.7

0.95

0.35

0.94

1.0

35

0.87

0.55

0.83

12.8

0.93

0.49

0.93

7.3

PSAd

0.10

0.93

0.31

0.82

7.3

0.97

0.28

0.95

2.8

0.15

0.81

0.57

0.77

18.6

0.90

0.53

0.92

9.6

0.20

0.69

0.77

0.73

31.3

0.80

0.72

0.88

20.0