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Table 2 Parameter estimates (95% CI) in England and in France

From: Transmissibility and pathogenicity of the emerging meningococcal serogroup W sequence type-11 complex South American strain: a mathematical modeling study

Quantity

Symbol

Value in England

Value in France*

Transmissibility of MenW:cc11/SA (relative to that of non-MenW:cc11)

r(β)

1.20 (1.15, 1.26)

1.15 (fixed)

1.20 (fixed)

1.26 (fixed)

Invasiveness of MenW:cc11/SA in 0–4 yo (relative to that of non-MenW:cc11 in 0–4 yo)

r(θ)I

4.0 (1.6, 9.7)

7.9 (fixed)

4.0 (fixed)

2.1 (fixed)

Invasiveness of MenW:cc11/SA in 5–24 yo (relative to that of MenW:cc11/SA in 0–4 yo)

r(θ)II

3.3 (2.1, 5.8)

3.6 (fixed)

3.2 (fixed)

3.3 (fixed)

Invasiveness of MenW:cc11/SA in 25+ yo (relative to that of MenW:cc11/SA in 5–24 yo)

r(θ)III

1.6 (1.1, 2.3)

1.3 (fixed)

1.5 (fixed)

1.4 (fixed)

Emergence time of MenW:cc11/SA carriage

t0

2009.5 (fixed)

2011.8 (2010.8, 2012.5)

2011.5 (2011.4, 2012.5)

2012.3 (2012.0, 2012.5)

Log-likelihood

− 85.5

− 80.4

− 90.5

− 101.8

  1. In England, the parameters were estimated using the iterated filtering algorithm, with the following algorithmic parameters: 150 iterations with 2000 particles, geometric cooling, and random walk standard deviation of 0.2 for each parameter. In both England and France, the log-likelihood of the parameters was calculated as the log of the mean likelihood of 5 replicate particle filters, each with 5000 particles. The log-likelihood profiles associated with each parameter estimate are shown in Additional file 1: Figs. S4 and S5. *MenW:cc11/SA parameters were not re-estimated in France, but fixed at 3 different values in the 95% CI of r(β) in England