Table 2 Comparison of visits for one RT-QuIC-positive study participant. RT-QuIC replicates were designated as positive based on the criteria described above, in the “Methods” section, and elsewhere [24]. CSF T-tau, NfL, and PrP were measured by ELISA as described in Figs. 1 and 2. Plasma NfL was measured by Simoa as described in Fig. 3
From: Cerebrospinal fluid and plasma biomarkers in individuals at risk for genetic prion disease
Visit 1 | Visit 2 | ||
|---|---|---|---|
Fluid biomarkers | CSF PrP (ng/mL) | 287 | 296 |
CSF T-tau (ng/mL) | 0.57 | 0.60 | |
CSF NfL (ng/mL) | 1.27 | 1.48 | |
Plasma NfL (pg/mL) | 23.5 | 28.8 | |
RT-QuIC (positive replicates) | 4/4 | 4/4 | |
Assessments | MRC prion disease rating scale | 20 | 20 |
Montreal Cognitive Assessment | 27 | 25 |