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Table 2 Comparison of visits for one RT-QuIC-positive study participant. RT-QuIC replicates were designated as positive based on the criteria described above, in the “Methods” section, and elsewhere [24]. CSF T-tau, NfL, and PrP were measured by ELISA as described in Figs. 1 and 2. Plasma NfL was measured by Simoa as described in Fig. 3

From: Cerebrospinal fluid and plasma biomarkers in individuals at risk for genetic prion disease

   Visit 1 Visit 2
Fluid biomarkers CSF PrP (ng/mL) 287 296
CSF T-tau (ng/mL) 0.57 0.60
CSF NfL (ng/mL) 1.27 1.48
Plasma NfL (pg/mL) 23.5 28.8
RT-QuIC (positive replicates) 4/4 4/4
Assessments MRC prion disease rating scale 20 20
Montreal Cognitive Assessment 27 25