|  | 12-week HAM-D, mean (SD) |  | |
---|---|---|---|---|
Method | Pre-registered | Optimal | Non-Optimal | p value†|
HAM-D-based SOrT allocation | ||||
 Valence | Yes | – | – | – |
 Median split | No | 8.50 (6.41) | 7.17 (5.86) | 0.091 |
 Extreme groups | Yes | 8.86 (6.65) | 7.08 (5.85) | 0.074 |
BDI-based SOrT allocation | ||||
 Valence | Yes | 7.62 (6.55) | 8.03 (5.97) | 0.617 |
 Median split | No | 7.63 (6.14) | 8.09 (6.24) | 0.563 |
 Extreme groups | Yes | 7.01 (6.16) | 7.66 (6.15) | 0.510 |