Fig. 2

TMB estimation model construction based on TCGA data in the training set. a The correlation of 23-gene TMB with WES-TMB is 0.9056, with an empirical p value of r of p < 0.0001. b The overall survival is significantly higher in the TMB-high group (≥ 4 mutational counts, n = 576) than in the TMB-low group (< 4 mutational counts, n = 414), with log-rank test p < 0.05. c The disease-free survival is significantly higher in the TMB-high group than in the TMB-low group, with log-rank test p < 0.01