|
Colorectal cancer
|
|---|
|
Variables
|
Men
|
Women
|
|---|
|
n cases/controls†
|
Odds ratio (95% CI)
|
P
|
Pheterogeneity
|
n cases/controls†
|
Odds ratio (95% CI)
|
P
|
Pheterogeneity
|
|---|
|
Adjusted model
|
658/658
|
1.19 (1.04–1.36)
|
0.01
| |
728/728
|
0.86 (0.76–0.97)
|
0.02
| |
|
Age at blood collection (year, median)
|
658/658
| | |
0.30
|
728/728
| | |
0.008
|
|
< 59.2/< 58.5
|
329/329
|
1.28 (1.06–1.54)
| | |
364/364
|
1.01 (0.85–1.19)
|
> 0.90
| |
|
≥ 59.2/≥ 58.5
|
329/329
|
1.10 (0.92–1.32)
| | |
364/364
|
0.73 (0.61–0.87)
|
0.001
| |
|
rs6431625 (increasing levels C allele)
|
333/333
| | |
0.02
|
428/428
| | |
0.14
|
|
TT genotype (wild-type)
|
117/139
|
1.1 (0.73–1.65)
|
0.60
| |
168/151
|
0.69 (0.49–0.99)
|
0.04
| |
|
TC genotype
|
160/146
|
0.92 (0.64–1.32)
|
0.60
| |
194/206
|
0.71 (0.53–0.95)
|
0.02
| |
|
CC genotype
|
56/48
|
2.01 (1.26–3.20)
|
0.003
| |
66/71
|
1.06 (0.74–1.53)
|
0.7
| |
|
Smoking status
|
658/658
| | |
0.40
|
728/728
| | |
0.20
|
|
Never
|
170/170
|
1.26 (1.00–1.59)
|
0.05
| |
427/427
|
0.83 (0.71–0.98)
|
0.03
| |
|
Former
|
294/294
|
1.06 (0.86–1.30)
|
0.60
| |
160/160
|
0.84 (0.66–1.07)
|
0.20
| |
|
Current
|
182/182
|
1.33 (1.08–1.64)
|
0.01
| |
137/137
|
0.99 (0.78–1.25)
|
0.90
| |
|
Unknown
|
12/12
|
0.93 (0.35–2.49)
|
0.90
| |
4/4
|
0.05 (0.00–0.1)
|
0.20
| |
|
Follow-up time (years)
|
658/658
| | |
0.20
|
728/728
| | |
0.60
|
|
1 (< 2)
|
141/141
|
0.96 (0.74–1.25)
|
0.80
| |
158/158
|
0.82 (0.65–1.05)
|
0.10
| |
|
2 (2–4)
|
173/173
|
1.34 (1.04–1.72)
|
0.02
| |
160/160
|
0.96 (0.76–1.23)
|
0.80
| |
|
3 (> 4)
|
244/244
|
1.23 (1.03–1.50)
|
0.02
| |
280/380
|
0.84 (0.71–0.99)
|
0.04
| |
- No effect modifications by BMI (median), alcohol consumption (median), menopausal status, and use of HT were observed (all P ≥ 0.7)
- Abbreviations: n number, P P value, CI confidence interval
- †Cases matched 1:1 to control subjects. EPIC (European Prospective Investigation into Cancer and Nutrition): Conditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) for associations between log-transformed UCB levels (log-UCB), standardized per one standard deviation (1-SD) increments, and CRC risk. The crude model was conditioned on the matching factors including study center, age at blood collection (1 year), fasting status and time (3 h intervals) at blood collection, among women, additionally by menopausal status (pre-, peri-, and post-menopausal or surgically menopausal), and hormone therapy (HT) (yes, no). The multivariable model was adjusted for level of education (none/primary school, technical/professional, secondary school, university degree), BMI, height, smoking status (never, former, current smoker), physical activity (inactive, moderately inactive, moderately active, active), alcohol consumption (g/day), dietary intakes of fiber (g/day), red meat (g/day), processed meats (g/day), dairy products (g/day), and total energy intake (kcal/day)
