Colorectal cancer |
|---|
| | Men | Women |
|---|
n cases/controls† | Odds ratio (95% CI) | P | n cases/controls† | Odds ratio (95% CI) | P |
|---|
Adjusted model | 658/658 | 1.19 (1.04–1.36) | 0.01 | 728/728 | 0.86 (0.76–0.97) | 0.02 |
Anatomical site | 658/658 | | > 0.9‡ | 728/728 | | 0.2‡ |
Colon | 381/381 | 1.18 (0.99–1.42) | 0.07 | 485/485 | 0.81 (0.70–0.95) | 0.008 |
Rectum | 277/277 | 1.19 (0.99–1.43) | 0.06 | 243/243 | 0.95 (0.62–0.79) | 0.79 |
Colon sub-site | 339/339 | | 0.1‡ | 447/447 | | 0.9‡ |
Proximal | 156/156 | 1.10 (0.83–1.47) | 0.5 | 218/218 | 0.77 (0.62–0.95) | 0.017 |
Distal | 183/183 | 1.55 (1.15–2.11) | 0.01 | 229/229 | 0.79 (0.62–1.00) | 0.06 |
- EPIC (European Prospective Investigation into Cancer and Nutrition): Conditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) for associations between log-transformed UCB levels (log-UCB), standardized per one standard deviation (1-SD) increments, and CRC risk. The crude model was conditioned on the matching factors including study center, age at blood collection (1 year), fasting status and time (3 h intervals) at blood collection, among women, additionally by menopausal status (pre-, peri-, and post-menopausal or surgically menopausal), and hormone therapy (HT) (yes, no). The multivariable model was adjusted for level of education (none/primary school, technical/professional, secondary school, and university degree), BMI, height, smoking status (never, former, current smoker), physical activity (inactive, moderately inactive, moderately active, and active), alcohol consumption (g/day), dietary intakes of fiber (g/day), red meat (g/day), processed meats (g/day), dairy products (g/d), and total energy intake (kcal/day)
- Abbreviations: n number, P P value, CI confidence interval
- †Cases matched 1:1 to control subjects
- ‡Pheterogeneity
