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Table 3 Hazard ratios for incident atrial fibrillation (AF) by quintiles of mtDNA copy number

From: Mitochondrial DNA copy number and incident atrial fibrillation

 

N events/N total

IR

Model 1*

Model 2†

Model 3‡

Model 4§

ARIC

 mtDNA-CN quintiles

  First

399/2029

10.9

1.26 (1.09, 1.46)

1.21 (1.05, 1.40)

1.20 (1.04, 1.39)

1.17 (0.99, 1.38)

  Second

355/2035

9.5

1.09 (0.94, 1.27)

1.11 (0.95, 1.29)

1.10 (0.94, 1.27)

1.18 (1.00, 1.40)

  Third

319/2037

8.5

0.97 (0.83, 1.13)

0.93 (0.80, 1.09)

0.94 (0.80, 1.09)

0.89 (0.74, 1.06)

  Fourth

356/2031

9.3

1.07 (0.92, 1.24)

1.08 (0.93, 1.25)

1.08 (0.93, 1.25)

1.08 (0.91, 1.28)

  Fifth

332/2017

8.9

Reference

Reference

Reference

Reference

p-trend

  

0.002

0.008

0.01

0.03

 10th vs 90th percentile

1761/10,149

9.4

1.20 (1.07, 1.34)

1.18 (1.05, 1.31)

1.16 (1.04, 1.30)

1.18 (1.04, 1.33)

MESA

 mtDNA-CN quintiles

  First

157/1154

12.4

1.04 (0.83, 1.30)

1.02 (0.82, 1.28)

1.01 (0.81, 1.26)

1.14 (0.90, 1.45)

  Second

150/1154

11.6

1.01 (0.81, 1.27)

0.99 (0.79, 1.24)

0.97 (0.78, 1.22)

1.06 (0.83, 1.36)

  Third

161/1166

12.3

1.04 (0.83, 1.30)

1.02 (0.82, 1.28)

1.02 (0.82, 1.27)

1.10 (0.87, 1.40)

  Fourth

169/1159

13.1

1.08 (0.87, 1.34)

1.05 (0.84, 1.31)

1.04 (0.83, 1.29)

1.10 (0.87, 1.39)

  Fifth

153/1148

11.8

Reference

Reference

Reference

Reference

p-trend

  

0.91

0.98

0.88

0.37

 10th vs 90th percentile

790/5781

12.2

1.05 (0.88, 1.25)

1.03 (0.87, 1.23)

1.03 (0.86, 1.23)

1.12 (0.93, 1.35)

CHS

 mtDNA-CN quintiles

  First

283/755

32.0

1.16 (0.98,1.38)

1.16 (0.98,1.37)

1.11 (0.93,1.31)

1.08 (0.89,1.32)

  Second

292/756

31.9

1.12 (0.95,1.32)

1.12 (0.95,1.32)

1.09 (0.92,1.28)

1.12 (0.92,1.35)

  Third

296/756

31.8

1.10 (0.94,1.30)

1.10 (0.94,1.30)

1.08 (0.92,1.28)

1.09 (0.90,1.32)

  Fourth

317/756

33.6

1.19 (1.01,1.39)

1.18 (1.00,1.39)

1.15 (0.98,1.35)

1.20 (1.00,1.45)

  Fifth

282/756

29.0

Reference

Reference

Reference

Reference

p-trend

  

0.16

0.18

0.38

0.65

 10th vs 90th percentile

1470/3779

31.6

1.12 (0.98,1.27)

1.11 (0.97,1.27)

1.07 (0.94,1.23)

1.07 (0.92,1.26)

Meta-analysis

 mtDNA-CN quintiles

  First

839/3938

14.4

1.18 (1.07, 1.30)

1.15 (1.05, 1.27)

1.13 (1.02, 1.25)

1.13 (1.01, 1.27)

  Second

797/3945

13.4

1.09 (0.98, 1.20)

1.09 (0.99, 1.20)

1.07 (0.97, 1.18)

1.13 (1.01, 1.27)

  Third

776/3959

12.9

1.03 (0.93, 1.14)

1.01 (0.92, 1.21)

1.00 (0.91, 1.11)

1.01 (0.90, 1.13)

  Fourth

842/3946

13.9

1.12 (1.01, 1.23)

1.11 (1.00, 1.22)

1.10 (0.99, 1.21)

1.13 (1.01, 1.26)

  Fifth

767/3921

12.8

Reference

Reference

Reference

Reference

p-trend

  

0.006

0.01

0.03

0.03

 10th vs 90th percentile

4021/19,709

13.5

1.14 (1.06, 1.23)

1.13 (1.04, 1.22)

1.11 (1.03, 1.20)

1.13 (1.04, 1.24)

  1. IR incidence rate (per 1000 person-years)
  2. *Model 1: adjusted for age, sex, and race/enrollment center groups
  3. †Model 2: further adjusted for body mass index, height, smoking, alcohol intake, and physical activity
  4. ‡Model 3: further adjusted for total and HDL cholesterol, cholesterol medication, hypertension, diabetes, prevalent heart failure, and eGFR at baseline
  5. §Model 4: further adjusted for log-transformed NT-proBNP
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