Colon capsule endoscopy versus CT colonography in FIT-positive colorectal cancer screening subjects: a prospective randomised trial—the VICOCA study

Table 2 Diagnostic performance (all figures are expressed as percentages) of colon capsule endoscopy and CT colonography, according to the intention-to-screen analysis

	CCE	95% CI	CTC	95% CI	Diff.	95% CI
Any neoplastic lesion¹ (regardless of size), no. (%)	112 (77.2)²		94 (66.7)²
Sensitivity	98.1	[94.1; 99.4]	64.8	[56.7; 72.2]	33.2	[22.8; 43.0]
Specificity	76.6	[68.8; 82.9]	95.7	[91.0; 98.0]	− 19.1	[− 35.6; − 2.4]
PPV	93.6	[88.2; 96.7]	96.8	[92.4; 98.7]	− 3.1	[− 9.5; 3.9]
NPV	92.0	[86.2; 95.4]	57.6	[49.4; 65.5]	34.3	[16.9; 48.7]
Accuracy	93.3	[87.9; 96.4]	75.1	[67.4; 81.5]	18.2	[9.7; 26.4]
Any neoplastic lesion¹ ≥ 6 mm, no. (%)³	77 (53.1)²		58 (41.1)²
Sensitivity	96.1	[91.1; 100]	79.3	[68.6; 88.8]	16.7	[5.2; 28.2]
Specificity	88.2	[79.6; 95.3]	96.3	[91.1; 100]	− 8.1	[− 17.1; 0.1]
PPV	90.2	[83.5; 96.1]	93.8	[85.7; 100]	− 3.6	[− 12.9; 6.5]
NPV	95.2	[89.2; 100]	86.9	[80.0; 93.2]	8.2	[0.9; 16.9]
Accuracy	92.4	[87.5; 96.5]	89.3	[83.6; 93.6]	3	[− 3.7; 9.8]
Any neoplastic lesion¹ ≥ 10 mm, no. (%)³	37 (25.5)²		40 (28.4)²
Sensitivity	97.3	[91.1; 100]	90.0	[83.9; 93.9]	7.3	[− 4.5; 18.6]
Specificity	95.3	[90.7; 99.0]	99.0	[95.6; 100]	− 3.6	[− 8.3; 1.2]
PPV	87.8	[76.7; 97.3]	97.3	[93.1; 100]	− 9.5	[− 21.2; 2.9]
NPV	99.0	[96.8; 100]	96.1	[91.5; 98.2]	2.8	[− 1.6; 7.4]
Accuracy	95.5	[92.4; 99.3]	96.4	[91.9; 98.4]	− 0.8	[− 5.2; 4.0]

CCE colon capsule endoscopy, CTC CT colonography, 95% CI 95% confidence interval, PPV positive predictive value, NPV negative predictive value, Diff. difference
¹Any neoplastic lesion includes cancer, advanced and non-advanced adenomas, and advanced and non-advanced serrated lesions
²Prevalence of patients with such lesions at colonoscopy
³Lesion size was estimated at colonoscopy

ISSN: 1741-7015