ADA | Allele/HT | AF (KI) | AF (TUM) | OR/β (Disc.) | p (Disc.) | OR/β (Repl.) | p(one-sided) (Repl.) | OR/β (Pool.) | p (Pool.) |
---|---|---|---|---|---|---|---|---|---|
All preparations: risk alleles | |||||||||
 bADA levels | HLA-DQA1*01:02 | 0.42 | 0.36 | 0.18β | 1.6 × 10−08 | 0.17β | 3.7 × 10−04 | 0.17β | 4.8 × 10−11 |
 bADA levels | B7-DQ6 | 0.18 | 0.17 | 0.17β | 8.6 × 10−06 | 0.21β | 3.8 × 10−04 | 0.18β | 2.7 × 10−08 |
All preparations: protective alleles | |||||||||
 bADA levels | DR3-DQ2 | 0.13 | 0.12 | − 0.23β | 9.6 × 10−08 | − 0.21β | 6.7 × 10−04 | − 0.23β | 5.0 × 10−10 |
IFNβ-1a s.c.: risk alleles | |||||||||
 nADA pres. | DR15-DQ6 | 0.34 | 0.30 | 2.73OR | 3.1 × 10−14 | 3.41OR | 1.5 × 10−07 | 2.89OR | 7.4 × 10−20 |
 nADA titer | DR15-DQ6 | 0.34 | 0.30 | 0.36β | 1.3 × 10−15 | 0.32β | 2.3 × 10−07 | 0.35β | 3.6 × 10−21 |
 bADA levels | DR15-DQ6 | 0.34 | 0.30 | 0.44β | 6.8 × 10−15 | 0.45β | 4.4 × 10−08 | 0.44β | 3.5 × 10−21 |
IFNβ-1a s.c.: protective alleles | |||||||||
 nADA pres. | DR3-DQ2 | 0.13 | 0.12 | 0.40OR | 9.1 × 10−07 | 0.29OR | 4.0 × 10−04 | 0.37OR | 3.7 × 10−09 |
 nADA titer | DR3-DQ2 | 0.13 | 0.12 | − 0.31β | 8.6 × 10−08 | − 0.28β | 5.0 × 10−04 | − 0.30β | 3.4 × 10−10 |
 bADA levels | DR3-DQ2 | 0.13 | 0.12 | − 0.41β | 2.1 × 10−08 | − 0.40β | 1.5 × 10−04 | − 0.41β | 2.5 × 10−11 |
IFNβ-1b s.c.: risk alleles | |||||||||
 nADA pres. | HLA-DRB1*04:01 | 0.09 | 0.07 | 6.82OR | 3.4 × 10−13 | 14.7OR | 1.7 × 10−07 | 7.95OR | 1.4 × 10−18 |
 nADA pres. | DR4-DQ3 | 0.07 | 0.05 | 6.23OR | 1.2 × 10−09 | 14.7OR | 6.1 × 10−06 | 7.35OR | 1.5 × 10−13 |
 nADA titer | HLA-DRB1*04:01 | 0.09 | 0.07 | 0.56β | 4.1 × 10−15 | 0.56β | 9.2 × 10−06 | 0.56β | 3.7 × 10−19 |
 nADA titer | DR4-DQ3 | 0.07 | 0.05 | 0.50β | 1.6 × 10−09 | 0.54β | 1.3 × 10−04 | 0.51β | 1.9 × 10−12 |
 bADA levels | HLA-DRB1*04:01 | 0.09 | 0.07 | 0.62β | 4.6 × 10−15 | 0.61β | 1.8 × 10−06 | 0.62β | 8.7 × 10−20 |
 bADA levels | DR4-DQ3 | 0.07 | 0.05 | 0.56β | 4.9 × 10−10 | 0.53β | 2.2 × 10−04 | 0.56β | 9.0 × 10−13 |