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Table 1 MR estimates from different methods of assessing the causal effect of IBD on BMDs

From: Mendelian randomization study of inflammatory bowel disease and bone mineral density

BMDs Step# No. of SNP IVW MBE WMM MR-Egger MR.RAPS
β (95%CI) P value Cochran Q statistics (df) P value β (95%CI) P value β (95%CI) P value Slope (95%CI) P value Intercept (Se) P value Cochran Q statistics (df) P value β (95%CI) P value
IBD and TB-BMD 3 119 − 0.017 (− 0.029, − 0.0046) 0.0067 146.2 (118) 0.040 − 0.0054 (− 0.031, 0.020) 0.67 − 0.0059 (− 0.024, 0.013) 0.53 − 0.016 (− 0.045, 0.013) 0.29 − 9.89e−5 (0.0016) 0.95 146.20 (117) 0.035 − 0.016 (− 0.028, − 0.0028) 0.017
IBD and FN-BMD 3 118 − 0.019 (− 0.035, − 0.0032) 0.018 140.57 (117) 0.068 − 0.049 (− 0.084, − 0.013) 0.0079 − 0.024 (− 0.047, − 0.00035) 0.047 − 0.0025 (− 0.039, 0.034) 0.90 − 0.0020 (0.0020) 0.33 139.42 (116) 0.068 − 0.018 (− 0.034, − 0.0014) 0.034
IBD and LS-BMD 3 120 − 0.012 (− 0.030, 0.0053) 0.17 135.03 (119) 0.15 − 0.034 (− 0.070, 0.0023) 0.069 − 0.029 (− 0.056, − 0.0018) 0.037 − 0.015 (− 0.057, 0.027) 0.48 0.00032 (0.0023) 0.89 125.00 (118) 0.14 − 0.013 (− 0.032, 0.0047) 0.15
IBD and FA-BMD 3 124 − 0.026 (− 0.057, 0.0058) 0.11 142.47 (123) 0.11 − 0.015 (− 0.084, 0.055) 0.68 − 0.017 (− 0.064, 0.029) 0.46 0.012 (− 0.063, 0.086) 0.76 − 0.0044 (0.0041) 0.29 141.14 (122) 0.11 − 0.028 (− 0.060, 0.0049) 0.095
IBD and TB-BMD(R*) 3 102 − 0.016 (− 0.027, − 5.46e−3) 0.0033 102.48 (101) 0.44 − 0.012 (− 0.037, 1.28e−2) 0.35 − 0.012 (− 0.030, 5.82e−3) 0.19 − 0.026 (− 0.052, − 9.06e−5) 0.052 0.0012 (0.0015) 0.42 101.82 (100) 0.43 − 0.016 (− 0.027, − 4.39e−3) 0.0064
IBD and FN-BMD(R*) 3 100 − 0.014 (− 0.030, 0.0014) 0.074 113.58 (99) 0.15 − 0.042 (− 0.078, − 0.0054) 0.027 − 0.028 (− 0.051, − 0.0044) 0.020 − 0.022 (− 0.058, 0.015) 0.24 0.00094 (0.0021) 0.66 113.36 (98) 0.14 − 0.015 (− 0.032, 0.0021) 0.086
IBD and LS-BMD(R*) 3 101 0.00062 (− 0.018, 0.020) 0.95 122.96 (100) 0.059 − 0.021 (− 0.056, 0.015) 0.27 − 0.022 (− 0.051, 0.0076) 0.15 − 0.030 (− 0.073, 0.013) 0.18 0.0039 (0.0025) 0.13 120.13 (99) 0.073 0.0023 (− 0.018, 0.022) 0.82
IBD and FA-BMD(R*) 3 105 − 0.026 (− 0.058, 0.0049) 0.098 116.14 (104) 0.20 − 0.012 (− 0. 082, 0.058) 0.75 − 0.011 (− 0.059, 0.037) 0.65 − 0.0017 (− 0.076, 0.073) 0.96 − 0.0031 (0.0044) 0.48 115.56 (103) 0.19 − 0.028 (− 0.062, 0.0051) 0.097
  1. Step#: 3, MR analysis after removing all the SNPs (with P value less than 1 in MR-PRESSO outlier test); R*, in replication practice
  2. TB-BMD total body bone mineral density, FN-BMD femoral neck bone mineral density, LS-BMD lumbar spine bone mineral density, FA-BMD forearm bone mineral density, β beta coefficient, Se standard error, SNP single nucleotide polymorphism, MR Mendelian randomization, IVW inverse variance weighting, MR-PRESSO MR-Pleiotropy RESidual Sum and Outlier method, MBE mode-based estimate method, WMM weighted median method, MR.RAPS robust adjusted profile score