Skip to main content

Table 2 MR estimates from different methods of assessing the causal effect of UC on BMDs

From: Mendelian randomization study of inflammatory bowel disease and bone mineral density

BMDs

Step#

No. of SNP

IVW

MBE

WMM

MR-Egger

MR.RAPS

β (95%CI)

P value

Cochran Q statistics (df)

P value

β (95%CI)

P value

β (95%CI)

P value

Slope (95%CI)

P value

Intercept (Se)

P value

Cochran Q statistics (df)

P value

β (95%CI)

P value

UC and TB-BMD

2

83

− 0.024 (− 0.037, − 0.012)

0.00011

96.49 (82)

0.13

− 0.0071 (− 0.038, 0.024)

0.67

− 0.023 (− 0.041, − 0.0053)

0.013

− 0.030 (− 0.061, 0.0016)

0.067

0.00069 (0.002)

0.73

96.34 (81)

0.12

− 0.024 (− 0.037, − 0.011)

0.00037

UC and FN-BMD

2

78

− 0.0082 (− 0.025, 0.0081)

0.32

84.27 (77)

0.27

0.020 (− 0.029, 0.068)

0.45

− 0.0095 (− 0.034, 0.015)

0.43

− 0.040 (− 0.079, − 0.00065)

0.0499

0.0043 (0.0025)

0.087

81.06 (76)

0.32

− 0.0085 (− 0.025, 0.0086)

0.33

UC and LS-BMD

2

80

− 0.013 (− 0.034, 0.0069)

0.20

100.64 (79)

0.051

− 0.027 (− 0.065, 0.012)

0.18

− 0.024 (− 0.051, 0.0031)

0.083

− 0.035 (− 0.085, 0.014)

0.17

0.0029 (0.0031)

0.36

99.51 (78)

0.051

− 0.014 (− 0.034, 0.0065)

0.18

UC and FA-BMD

1

82

− 0.064 (− 0.096, − 0.032)

7.79e−5

82.65 (81)

0.43

− 0.031 (− 0.098, 0.036)

0.38

− 0.052 (0.10, − 0.0052)

0.025

− 0.061 (− 0.14, 0.019)

0.14

− 0.00038 (0.0050)

0.94

82.65 (80)

0.40

− 0.062 (− 0.095, − 0.029)

2.22e−4

UC and TB-BMD(R*)

2

72

− 0.021 (− 0.033, − 0.0086)

0.00086

83.88 (71)

0.14

− 0.021 (− 0.044, 0.0027)

0.087

− 0.023 (− 0.041, − 0.0059)

0.025

− 0.028 (− 0.058, 0.0013)

0.065

0.0011 (0.0020)

0.59

83.53 (70)

0.13

− 0.022 (− 0.035, − 0.0084)

0.0014

UC and FN-BMD(R*)

1

68

− 0.0082 (− 0.025, 0.0087)

0.34

82.25 (67)

0.099

0.0089 (− 0.028, 0.046)

0.64

0.0039 (− 0.022, 0.029)

0.77

− 0.026 (− 0.064, 0.012)

0.19

0.0026 (0.0026)

0.31

80.98 (66)

0.10

− 0.0087 (− 0.027, 0.0094)

0.35

UC and LS-BMD(R*)

3

64

− 0.0094 (− 0.027, 0.0086)

0.30

63.60 (63)

0.46

− 0.015 (− 0.049, 0.019)

0.39

− 0.016 (− 0.043, 0.012)

0.27

− 0.029 (− 0.069, 0.011)

0.16

0.0030 (0.0028)

0.29

62.45 (62)

0.46

− 0.011 (− 0.030, 0.0080)

0.26

UC and FA-BMD(R*)

1

72

− 0.044 (− 0.075, − 0.014)

0.0043

59.11 (71)

0.84

− 0.039 (− 0.10, 0.023)

0.22

− 0.043 (− 0.092, 0.0056)

0.083

− 0.076 (− 0.15, − 0.0052)

0.039

0.0047 (0.0048)

0.33

58.16 (70)

0.84

− 0.044 (− 0.076, − 0.012)

0.0074

  1. Step#: 1, MR analysis with the complete selected SNPs; 2, MR analysis after removing the SNPs (with P value less than threshold in MR-PRESSO outlier test); 3, MR analysis after removing all the SNPs (with P value less than 1 in MR-PRESSO outlier test); R*, in replication practice
  2. TB-BMD total body bone mineral density, FN-BMD femoral neck bone mineral density, LS-BMD lumbar spine bone mineral density, FA-BMD forearm bone mineral density, β beta coefficient, Se standard error, SNP single nucleotide polymorphism, MR Mendelian randomization, IVW inverse variance weighting, MR-PRESSO MR-Pleiotropy RESidual Sum and Outlier method, MBE mode-based estimate method, WMM weighted median method, MR.RAPS robust adjusted profile score
Back to article page

BMC Medicine

ISSN: 1741-7015

Contact us