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Table 2 MR estimates from different methods of assessing the causal effect of UC on BMDs

From: Mendelian randomization study of inflammatory bowel disease and bone mineral density

BMDs Step# No. of SNP IVW MBE WMM MR-Egger MR.RAPS
β (95%CI) P value Cochran Q statistics (df) P value β (95%CI) P value β (95%CI) P value Slope (95%CI) P value Intercept (Se) P value Cochran Q statistics (df) P value β (95%CI) P value
UC and TB-BMD 2 83 − 0.024 (− 0.037, − 0.012) 0.00011 96.49 (82) 0.13 − 0.0071 (− 0.038, 0.024) 0.67 − 0.023 (− 0.041, − 0.0053) 0.013 − 0.030 (− 0.061, 0.0016) 0.067 0.00069 (0.002) 0.73 96.34 (81) 0.12 − 0.024 (− 0.037, − 0.011) 0.00037
UC and FN-BMD 2 78 − 0.0082 (− 0.025, 0.0081) 0.32 84.27 (77) 0.27 0.020 (− 0.029, 0.068) 0.45 − 0.0095 (− 0.034, 0.015) 0.43 − 0.040 (− 0.079, − 0.00065) 0.0499 0.0043 (0.0025) 0.087 81.06 (76) 0.32 − 0.0085 (− 0.025, 0.0086) 0.33
UC and LS-BMD 2 80 − 0.013 (− 0.034, 0.0069) 0.20 100.64 (79) 0.051 − 0.027 (− 0.065, 0.012) 0.18 − 0.024 (− 0.051, 0.0031) 0.083 − 0.035 (− 0.085, 0.014) 0.17 0.0029 (0.0031) 0.36 99.51 (78) 0.051 − 0.014 (− 0.034, 0.0065) 0.18
UC and FA-BMD 1 82 − 0.064 (− 0.096, − 0.032) 7.79e−5 82.65 (81) 0.43 − 0.031 (− 0.098, 0.036) 0.38 − 0.052 (0.10, − 0.0052) 0.025 − 0.061 (− 0.14, 0.019) 0.14 − 0.00038 (0.0050) 0.94 82.65 (80) 0.40 − 0.062 (− 0.095, − 0.029) 2.22e−4
UC and TB-BMD(R*) 2 72 − 0.021 (− 0.033, − 0.0086) 0.00086 83.88 (71) 0.14 − 0.021 (− 0.044, 0.0027) 0.087 − 0.023 (− 0.041, − 0.0059) 0.025 − 0.028 (− 0.058, 0.0013) 0.065 0.0011 (0.0020) 0.59 83.53 (70) 0.13 − 0.022 (− 0.035, − 0.0084) 0.0014
UC and FN-BMD(R*) 1 68 − 0.0082 (− 0.025, 0.0087) 0.34 82.25 (67) 0.099 0.0089 (− 0.028, 0.046) 0.64 0.0039 (− 0.022, 0.029) 0.77 − 0.026 (− 0.064, 0.012) 0.19 0.0026 (0.0026) 0.31 80.98 (66) 0.10 − 0.0087 (− 0.027, 0.0094) 0.35
UC and LS-BMD(R*) 3 64 − 0.0094 (− 0.027, 0.0086) 0.30 63.60 (63) 0.46 − 0.015 (− 0.049, 0.019) 0.39 − 0.016 (− 0.043, 0.012) 0.27 − 0.029 (− 0.069, 0.011) 0.16 0.0030 (0.0028) 0.29 62.45 (62) 0.46 − 0.011 (− 0.030, 0.0080) 0.26
UC and FA-BMD(R*) 1 72 − 0.044 (− 0.075, − 0.014) 0.0043 59.11 (71) 0.84 − 0.039 (− 0.10, 0.023) 0.22 − 0.043 (− 0.092, 0.0056) 0.083 − 0.076 (− 0.15, − 0.0052) 0.039 0.0047 (0.0048) 0.33 58.16 (70) 0.84 − 0.044 (− 0.076, − 0.012) 0.0074
  1. Step#: 1, MR analysis with the complete selected SNPs; 2, MR analysis after removing the SNPs (with P value less than threshold in MR-PRESSO outlier test); 3, MR analysis after removing all the SNPs (with P value less than 1 in MR-PRESSO outlier test); R*, in replication practice
  2. TB-BMD total body bone mineral density, FN-BMD femoral neck bone mineral density, LS-BMD lumbar spine bone mineral density, FA-BMD forearm bone mineral density, β beta coefficient, Se standard error, SNP single nucleotide polymorphism, MR Mendelian randomization, IVW inverse variance weighting, MR-PRESSO MR-Pleiotropy RESidual Sum and Outlier method, MBE mode-based estimate method, WMM weighted median method, MR.RAPS robust adjusted profile score