Table 3 Health and economic parameters used in the cost-effectiveness analysis
Parameter | Mean value (95% CI where applicable) | Reference | |
|---|---|---|---|
T | Time horizon | 10 years | – |
r | Discount rate | 3.5% | [7] |
Probability of clinical outcomes | |||
rGa | Per-infection probability of GP consultation | 0–4 years: 0.006–0.065 | [41] |
5–14 years: 0.017–0.018 | [44] | ||
15+ years: 0.014–0.132 | [42] | ||
rDa | Per-infection probability of death | 0–4 years: 8.197 × 10−6–3.698 × 10−5 | [41] |
5–14 years: 6.731 × 10−6–6.896 × 10−6 | [44] | ||
15+ years: 4.663 × 10−6–0.002 | [42] | ||
rHa,r | Per-infection probability of hospital admissions | VHR, 0–8 months: 0.133–0.391 | [57] |
HR, 0–11 months: 0.013–0.130 | [46] | ||
NR, 0–11 months: 0.010–0.097 | [46] | ||
NR, 1–4 years: 0.004–0.008 | [29] | ||
NR, 5–64 years: 4.688 × 10−5–8.004 × 10−5 | [44] | ||
NR, 65+ years: 6.197 × 10−5–0.019 | [42] | ||
rBa,r | Number of hospital bed days per hospitalisation | VHR, 0–8 months: 8–25 | [57] |
HR, 0–11 months: 5–7 | [46] | ||
NR, 0–11 months: 1–5 | [46] | ||
NR, 1–64 years: 2 | [47] | ||
NR, 65+ years: 3 | [48] | ||
Costs | |||
Per GP visit | |||
ΘGP | All ages | £36.00 (fixed) | |
Per hospital bed day | |||
ΘaH | Paediatric (< 5 years of age) | £725.29 (718.13–733.99)1 | [56] |
ΘaH | Adult (≥ 5 years of age) | £425.24 (415.16–435.70)2 | [56] |
Administration of prophylactics (per course) | |||
Δpal | Palivizumab | £57.50 (fixed) | [54] |
Δmab | La-mABs | £11.00 (fixed) | [54] |
Δmat | Maternal vaccine | £9.00 (fixed) | [54] |
Δvac | Vaccine | £9.00 (fixed) | [54] |
Purchasing prices (per course) | |||
ρpal | Palivizumab | £4035.50 (fixed) | [56] |
ρX | La-mABs, Maternal vaccine and vaccine | Not known | |
QALY loss | |||
Symptomatic infection | |||
QaS | Paediatric (< 5 years of age) | 2.336 × 10−3 (0.269 × 10−3–9.255 × 10−3)3 | [52] |
QaS | Adult (≥5 years of age) | 1.448 × 10−3 (0.135 × 10−3–5.928 × 10−3)4 | [52] |
Hospital admissions | |||
QaH | Paediatric (< 5 years of age) | 4.098 × 10−3 (0.624 × 10−3–13.141 × 10−3)5 | [52] |
QaH | Adult (≥5 years of age) | 2.990 × 10−3 (0.346 × 10−3–11.387 × 10−3)6 | [52] |
Deaths | |||
Life expectancy | 81.0 years | [51] | |
QaS | Age-specific QALY loss | See Additional file 1: Section 5.2. | |