Skip to main content

Table 2 Analysis of factors associated with mortality at 6 months

From: The efficacy and safety of methylprednisolone in hepatitis B virus-related acute-on-chronic liver failure: a prospective multi-center clinical trial

Factors Univariate Multivariate
HR(95%CI) P value HR(95%CI) P value
Methylprednisolone 0.584 (0.349–0.976) 0.040 0.547 (0.308–0.973) 0.040
 Centers a 0.683   
 Cirrhosis 1.114 (0.566–2.194) 0.755   
 Antiviral treatment a 0.410   
 Male 0.594 (0.293–1.205) 0.149   
 Age (years) 1.024 (1.004–1.045) 0.019 1.012 (0.987–1.037) 0.359
 Time from onset to admission (days) 1.008 (0.993–1.024) 0.304   
 MELD score 1.123 (1.072–1.176) 0.000   
 lg HBV DNA (IU/ml) 0.973 (0.851–1.112) 0.686   
 HBV DNA positive 0.617 (0.313–1.218) 0.164   
 HBeAg positive 0.726 (0.439–1.201) 0.213   
 HBsAg 1.000 (1.000–1.000) 0.248   
 ALT(U/L) 0.999 (0.999–1.000) 0.092   
 AST(U/L) 1.000 (0.999–1.001) 0.859   
Bilirubin (μmol/L) 1.004 (1.002–1.005) 0.000 1.003 (1.001–1.005) 0.004
 Albumin(g/L) 0.985 (0.924–1.050) 0.648   
 Cholinesterase (IU/L) 1.000 (1.000–1.000) 0.893   
 AFP (ng/ml) 0.999 (0.997–1.001) 0.228   
Blood urea nitrogen (mmol/L) 1.149 (1.049–1.260) 0.003 1.195 (1.018–1.402) 0.029
 Creatinine (μmol/L) 1.006 (1.001–1.011) 0.020 0.995 (0.984–1.005) 0.318
 NH3(μg/dl) 1.002 (0.997–1.008) 0.413   
 Triglyceride (mmol/L) 0.628 (0.401–0.986) 0.043 0.905 (0.524–1.561) 0.719
 Cholesterol (mmol/L) 0.835 (0.585–1.190) 0.319   
 White blood cell(× 109/L) 1.057 (0.986–1.133) 0.115   
 Lymphocyte percentage 0.934 (0.903–0.966) 0.000 0.950 (0.883–1.023) 0.175
Monocyte percentage 1.103 (1.023–1.190) 0.011 1.149 (1.011–1.307) 0.034
 Lymphocyte to monocyte ratio 0.497 (0.366–0.674) 0.000 0.838 (0.468–1.502) 0.553
 Neutrophil percentage 1.037 (1.012–1.062) 0.003   
 Procalcitonin (μg/L) 0.993 (0.871–1.132) 0.913   
PTA (%) 0.942 (0.914–0.970) 0.000 0.931 (0.870–0.996) 0.038
 INR 2.272 (1.482–3.493) 0.000 0.918 (0.320–2.629) 0.873
 Red blood cell(× 1012/L) 0.959 (0.711–1.293) 0.782   
 Hemoglobin(g/L) 0.998 (0.986–1.009) 0.702   
 Platelet(× 109/L) 0.996 (0.991–1.002) 0.163   
 Ascites 2.021 (1.154–3.539) 0.014 0.879 (0.467–1.656) 0.690
 Infections 1.381 (0.826–2.308) 0.218   
 Electrolyte disturbance 0.599 (0.217–1.651) 0.322   
 HE 2.161 (1.148–4.066) 0.017 1.270 (0.629–2.564) 0.505
 Hypoalbuminemia 1.010 (0.537–1.900) 0.975   
 HRS 4.296 (1.544–11.954) 0.005 1.013 (0.216–4.753) 0.987
  1. aRisk estimate statistics cannot be computed. They are only computed for two groups of data