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Table 1 Comparison of those included and not included in the interaction cohort

From: Multimorbidity, polypharmacy, and drug-drug-gene interactions following a non-ST elevation acute coronary syndrome: analysis of a multicentre observational study

Characteristic Interaction cohort, n = 652 Not in interaction cohort, n = 804 Unadjusted p value
Demographics
 Sex (male), n (%) 457 (70.1) 600 (74.6) 0.040
 Age (years), mean (SD) 66.0 (11.5) 64.4 (11.8) 0.012
 BMI, median (IQR) 28.3 (25.3–31.8) 27.9 (24.9–31.4) 0.21
Comorbidities
 Smoking, n (%) 185 (28.4) 180 (22.4) 0.011
 Cardiovascular multimorbidity 218 (33.4) 175 (21.8) 6.1 × 10−7
 Non-cardiovascular multimorbidity 167 (25.6) 98 (12.2) 4.1 × 10−11
 All multimorbidity 385 (59.0) 342 (42.5) 3.7 × 10−10
 Number of comorbidities, n (%)
  0 116 (17.8) 205 (25.5) 5.0 × 10−4
  1 151 (23.2) 257 (32.0)
  2 152 (23.3) 174 (21.6)
  3 107 (16.4) 105 (13.1)
  4–5 117 (17.9) 55 (6.8)
  6–7 9 (1.4) 8 (1.0)
Index NSTE-ACS
 Raised troponin, n (%) 623 (95.6) 765 (95.1) 0.45
 Coronary catheterisation, n (%) 445 (68.3) 529 (65.8) 0.32
 PCI/CABG, n (%) 283 (43.4) 376 (46.8) 0.20
Cardiovascular drugs at discharge
 Aspirin, n (%) 612 (93.9) 758 (94.3) 0.52
 P2Y12 inhibitor, n (%) 556 (85.3) 680 (84.6) 0.81
 ACEI/ARB, n (%) 540 (82.8) 651 (81.0) 0.39
 Beta blocker, n (%) 528 (81.0) 664 (82.6) 0.34
 Statin, n (%) 609 (93.4) 767 (95.4) 0.026
 Number of patients on all five secondary prevention cardiovascular drugs, n (%) 373 (57.2) 464 (57.7) 0.84
 Number of cardiovascular drugs/patient, median (IQR, range)†† 6 (5–7, 0–9) 6 (5–6, 2–10) 0.11
  1. ACEI angiotensin-converting enzyme inhibitor, ARB angiotensin II receptor blocker, CABG coronary artery bypass graft surgery, IQR interquartile range, n (%) number (percent) of patients, PCI percutaneous coronary intervention, SD standard deviation
  2. Secondary prevention cardiovascular drugs were aspirin, P2Y12 inhibitor, ACEI/ARB, beta blocker, and a statin
  3. ††Includes secondary prevention and other cardiovascular drugs