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Table 1 Comparison of those included and not included in the interaction cohort

From: Multimorbidity, polypharmacy, and drug-drug-gene interactions following a non-ST elevation acute coronary syndrome: analysis of a multicentre observational study

Characteristic

Interaction cohort, n = 652

Not in interaction cohort, n = 804

Unadjusted p value

Demographics

 Sex (male), n (%)

457 (70.1)

600 (74.6)

0.040

 Age (years), mean (SD)

66.0 (11.5)

64.4 (11.8)

0.012

 BMI, median (IQR)

28.3 (25.3–31.8)

27.9 (24.9–31.4)

0.21

Comorbidities

 Smoking, n (%)

185 (28.4)

180 (22.4)

0.011

 Cardiovascular multimorbidity

218 (33.4)

175 (21.8)

6.1 × 10−7

 Non-cardiovascular multimorbidity

167 (25.6)

98 (12.2)

4.1 × 10−11

 All multimorbidity

385 (59.0)

342 (42.5)

3.7 × 10−10

 Number of comorbidities, n (%)

  0

116 (17.8)

205 (25.5)

5.0 × 10−4

  1

151 (23.2)

257 (32.0)

  2

152 (23.3)

174 (21.6)

  3

107 (16.4)

105 (13.1)

  4–5

117 (17.9)

55 (6.8)

  6–7

9 (1.4)

8 (1.0)

Index NSTE-ACS

 Raised troponin, n (%)

623 (95.6)

765 (95.1)

0.45

 Coronary catheterisation, n (%)

445 (68.3)

529 (65.8)

0.32

 PCI/CABG, n (%)

283 (43.4)

376 (46.8)

0.20

Cardiovascular drugs at discharge

 Aspirin, n (%)

612 (93.9)

758 (94.3)

0.52

 P2Y12 inhibitor, n (%)

556 (85.3)

680 (84.6)

0.81

 ACEI/ARB, n (%)

540 (82.8)

651 (81.0)

0.39

 Beta blocker, n (%)

528 (81.0)

664 (82.6)

0.34

 Statin, n (%)

609 (93.4)

767 (95.4)

0.026

 Number of patients on all five secondary prevention cardiovascular drugs, n (%)†

373 (57.2)

464 (57.7)

0.84

 Number of cardiovascular drugs/patient, median (IQR, range)††

6 (5–7, 0–9)

6 (5–6, 2–10)

0.11

  1. ACEI angiotensin-converting enzyme inhibitor, ARB angiotensin II receptor blocker, CABG coronary artery bypass graft surgery, IQR interquartile range, n (%) number (percent) of patients, PCI percutaneous coronary intervention, SD standard deviation
  2. †Secondary prevention cardiovascular drugs were aspirin, P2Y12 inhibitor, ACEI/ARB, beta blocker, and a statin
  3. ††Includes secondary prevention and other cardiovascular drugs