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Table 2 Peak severity of symptoms up to 6 h after consuming gluten

From: Patient factors influencing acute gluten reactions and cytokine release in treated coeliac disease

  Gluten reaction severity All
None Very mild Mild Moderate Severe Very severe
Number of patients (%) 8 (3) 33 (11) 65 (22) 104 (35) 54 (18) 31 (10) 295
Median peak hourly severity of digestive symptoms rated each hour in the Global Symptom Survey (interquartile range)
 Absolute value 0 (0–0) 2 (1–2) 2 (1–2) 6 (5–6) 8 (8–8) 10 (9–10) 5 (3–8)
 Change from baseline 0 (0–0) 1 (1–2) 1 (1–2) 5 (5–6) 8 (7–8) 10 (9–10) 5 (3–7)
Median peak hourly symptom score in modified CeD PRO (interquartile range)
 Nausea 0 (0–0) 1 (0–2) 2 (1–4) 5 (3–6) 8 (7–9) 10 (10–10) 4 (2–8)
 Diarrhoea 0 (0–0) 0 (0–0) 0 (0–0) 0 (0–1) 1 (0–6) 8 (1–10) 0 (0–3)
 Loose stool 0 (0–0) 0 (0–0) 0 (0–1) 0 (0–3) 2 (0–8) 8 (2–10) 0 (0–3)
 Cramping 0 (0–1) 1 (0–1) 2 (1–3) 4 (2–5) 7 (4–8) 8 (6–9) 4 (1–6)
 Pain 0 (0–1) 1 (0–1) 2 (1–3) 4 (3–5) 6 (5–8) 8 (6–9) 4 (1–6)
 Tiredness 2 (0–3) 2 (1–3) 3 (2–5) 6 (4–7) 7 (7–8) 6 (5–8) 5 (3–7)
 Bloating 0 (0–0) 2 (1–2) 3 (2–3) 5 (3–6) 7 (5–7) 5 (3–7) 4 (2–6)
 Gas 0 (0–0) 1 (1–2) 2 (1–3) 3 (2–4) 4 (2–6) 4 (1–7) 2 (1–4)
 Headache 0 (0–0) 1 (0–3) 2 (0–4) 4 (2–6) 3 (1–8) 2 (1–6) 3 (1–5)
  1. Peak overall severity was the worst hourly descriptor rating reported by patients over 6 h after gluten challenge in the Global Symptom Survey for the question, “Overall, how would you rate the severity of your digestive symptoms in the past 1 h? (e.g. feeling or being sick, abdominal pain or cramps, feeling bloated, having loose stools or passing gas)”
  2. Whole number rating scale from 0 for no symptoms to 10 for worst possible symptoms