Table 2 Peak severity of symptoms up to 6 h after consuming gluten
From: Patient factors influencing acute gluten reactions and cytokine release in treated coeliac disease
Gluten reaction severity‡ | All | ||||||
|---|---|---|---|---|---|---|---|
None | Very mild | Mild | Moderate | Severe | Very severe | ||
Number of patients (%) | 8 (3) | 33 (11) | 65 (22) | 104 (35) | 54 (18) | 31 (10) | 295 |
Median peak hourly severity of digestive symptoms rated each hour in the Global Symptom Survey† (interquartile range) | |||||||
Absolute value | 0 (0–0) | 2 (1–2) | 2 (1–2) | 6 (5–6) | 8 (8–8) | 10 (9–10) | 5 (3–8) |
Change from baseline | 0 (0–0) | 1 (1–2) | 1 (1–2) | 5 (5–6) | 8 (7–8) | 10 (9–10) | 5 (3–7) |
Median peak hourly symptom score in modified CeD PRO† (interquartile range) | |||||||
Nausea | 0 (0–0) | 1 (0–2) | 2 (1–4) | 5 (3–6) | 8 (7–9) | 10 (10–10) | 4 (2–8) |
Diarrhoea | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–1) | 1 (0–6) | 8 (1–10) | 0 (0–3) |
Loose stool | 0 (0–0) | 0 (0–0) | 0 (0–1) | 0 (0–3) | 2 (0–8) | 8 (2–10) | 0 (0–3) |
Cramping | 0 (0–1) | 1 (0–1) | 2 (1–3) | 4 (2–5) | 7 (4–8) | 8 (6–9) | 4 (1–6) |
Pain | 0 (0–1) | 1 (0–1) | 2 (1–3) | 4 (3–5) | 6 (5–8) | 8 (6–9) | 4 (1–6) |
Tiredness | 2 (0–3) | 2 (1–3) | 3 (2–5) | 6 (4–7) | 7 (7–8) | 6 (5–8) | 5 (3–7) |
Bloating | 0 (0–0) | 2 (1–2) | 3 (2–3) | 5 (3–6) | 7 (5–7) | 5 (3–7) | 4 (2–6) |
Gas | 0 (0–0) | 1 (1–2) | 2 (1–3) | 3 (2–4) | 4 (2–6) | 4 (1–7) | 2 (1–4) |
Headache | 0 (0–0) | 1 (0–3) | 2 (0–4) | 4 (2–6) | 3 (1–8) | 2 (1–6) | 3 (1–5) |