Table 5 Univariable and multivariable logistic regression of factors associated with being a subsequent TB case in a cluster (a surrogate for recent infection) compared to being the first case or a non-clustered case, in England, Wales and Northern Ireland from 2010 to 2014
|  | Univariable OR (95% CI) | Multivariable≠OR (95% CI) |
|---|---|---|
HIV status | ||
 Negative | 1.00 | 1.00 |
 Positive | 0.85 (0.73–0.98) | 0.82 (0.69–0.98) |
Year of TB notification | ||
 2010 | 1.00 | 1.00 |
 2011 | 1.87 (1.70–2.07) | 2.06 (1.84–2.31) |
 2012 | 2.60 (2.36–2.87) | 3.06 (2.74–3.43) |
 2013 | 2.91 (2.63–3.22) | 3.38 (3.02–3.80) |
 2014 | 2.74 (2.48–3.04) | 3.17 (2.82–3.56) |
Sex | ||
 Female | 1.00 |  |
 Male | 1.10 (1.04–1.17) | 1.09 (1.02–1.17) |
Age (years) | ||
 15–24 | 1.35 (1.24–1.47) | 1.19 (1.08–1.32) |
 25–34 | 1.00 | 1.00 |
 35–44 | 1.05 (0.96–1.14) | 0.92 (0.83–1.02) |
 45–54 | 1.20 (1.09–1.32) | 0.90 (0.80–1.01) |
 55–64 | 1.21 (1.07–1.35) | 0.96 (0.83–1.10) |
 65+ | 0.71 (0.64–0.78) | 0.51 (0.45–0.57) |
Ethnicity | ||
 White | 1.00 | 1.00 |
 Black African | 1.03 (0.94–1.13) | 1.51 (1.31–1.73) |
 Black Other | 2.06 (1.72–2.47) | 2.25 (1.82–2.78) |
 Indian sub-continent | 0.72 (0.66–0.77) | 0.92 (0.81–1.04) |
 Mixed/other | 0.71 (0.65–0.79) | 0.98 (0.85–1.13) |
Time since entry to the UK | ||
 UK born | 1.00 | 1.00 |
 Within 2 years | 0.49 (0.44–0.54) | 0.41 (0.36–0.47) |
 2–5 years | 0.49 (0.44–0.53) | 0.39 (0.35–0.44) |
 5–10 years | 0.56 (0.51–0.62) | 0.49 (0.43–0.55) |
 More than 10 years | 0.65 (0.59–0.70) | 0.61 (0.54–0.69) |
TB lineage | ||
 Beijing | 1.00 | 1.00 |
 Euro-American | 0.47 (0.41–0.54) | 0.38 (0.33–0.45) |
 Central Asian Strain | 0.58 (0.50–0.66) | 0.63 (0.54–0.74) |
 East Asian Indian | 0.23 (0.19–0.26) | 0.23 (0.19–0.28) |
 Other | 0.37 (0.31–0.42) | 0.32 (0.27–0.38) |
IMD decile | ||
 For each decile increase | 0.97 (0.96–0.98) | 0.98 (0.96–0.99) |
Drug misuse | ||
 No | 1.00 | 1.00 |
 Yes | 2.62 (2.24–3.08) | 1.53 (1.25–1.87) |
Alcohol misuse | ||
 No | 1.00 | 1.00 |
 Yes | 1.65 (1.43–1.91) | 1.21 (1.01–1.45) |
Homelessness | ||
 No | 1.00 | 1.00 |
 Yes | 1.58 (1.35–1.84) | 1.03 (0.85–1.24) |
Imprisonment | ||
 No | 1.00 | 1.00 |
 Yes | 2.16 (1.84–2.54) | 1.26 (1.03–1.54) |