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Table 2 Prevalence of silent cerebral infarcts in HbSS and HbSβ0 sickle cell disease patients

From: Silent cerebral infarcts in patients with sickle cell disease: a systematic review and meta-analysis

Author (year)

Study design

Sample size

Mean age (years)

Field strength (T)

Prevalence SCIs (%)

Abboud et al. 2011 [19]

PCS

77

12.3

NA

26.6

Arkuszewski et al. 2014 [20]

PCS

67

8.8

3.0

37.7

Asbeutah et al. 2014 [21]

PCS

40

10.1*

1.5

10

de Blank et al. 2010 [24]

RCS

254

10.6

NA

30.7

Brousse et al. 2017 [25]

PCS

59

11.4

NA

13.6

Brown et al. 2000 [26]

PCS

48

9.8*

NA

22.9

Calvet et al. 2017 [27]

RCS

83

43.3

3.0

49.4

Ford et al. 2017 [30]

PCS

22

27

NA

54.5

Ford et al. 2018 [31]

PCS

1061

NA

NA

27

Guilliams et al. 2015 [33]

RCS

168

NA

1.5/3.0

27.4

Gyang et al. 2011 [34]

RCS

8

15

NA

50

Kassim et al. 2016 [36]

RCS

60

30

NA

53.3

Kwiatkowski et al. 2009 [6]

RCS

65

3.6

1.5

27.7

Marouf et al. 2003 [67]

PCS

35

26.9

NA

20

Mercuri et al. 1995 [39]

PCS

11

9.3

1.0

45.5

Nottage et al. 2016 [68]

PCS

50

9.4

NA

38

Oguz et al. 2003 [40]

PCS

18

8.7

1.5

5.6

Pegelow et al. 2002 [10]

RCS

266

8.3*

NA

21.8

Schatz et al. 2005 [44]

PCS

20

12.2**

1.5

40

Silva et al. 2009 [46]

PCS

46

26.8

1.5

56.5

Tewari et al. 2018 [49]

PCS

51

12.4**

NA

37.3

Václavů et al. 2019 [50]

PCS

36

31.9

3.0

80.6

Van der Land et al. 2015 [51]

PCS

10

23

3.0/7.0

50

Van der Land et al. 2016 [52]

PCS

34

12.1

3.0

41.2

Vichinsky et al. 2010 [53]

PCS

141

31.6

1.5

28.9

Wang et al. 1998 [54]

PCS

36

1.5

1.5

8.3

Wang et al. 2008 [55]

PCS

23

1.1

1.5

13

  1. SCIs silent cerebral infarctions, PCS prospective cohort study (including case-control and randomized controlled trial), RCS retrospective cohort study, NA not available
  2. *Only the mean age for the full sample was provided, not separately for HbSS and HbSβ0 thalassemia patients
  3. **Only the mean age for the SCI-affected and SCI-unaffected group separately was provided, not for the full sample