Table 4 Summary of the risk factors for MRI-defined silent cerebral infarcts in sickle cell disease analysed in multivariate models
From: Silent cerebral infarcts in patients with sickle cell disease: a systematic review and meta-analysis
Risk factors | OR/HR* (95% CI) | p value | Study |
|---|---|---|---|
Male sex | NA | 0.030 | DeBaun et al. 2012** [70] |
Higher SBP | NA | 0.018 | DeBaun et al. 2012** [70] |
NA | 0.015 | Sarnaik et al. 2009 [74] | |
Higher WBC count | 3.23 (1.24–14.37) | 0.016 | Kinney et al. 1999 [72] |
Lower Hb level | 1.75 (1.14–2.78) | 0.011 | Bernaudin et al. 2011 [23] |
2.88 (1.05–7.87) | 0.039 | Bernaudin et al. 2015 [58] | |
NA | 0.001 | DeBaun et al. 2012** [70] | |
Lower HbF% | 0.84 (0.72–0.97) | 0.02 | Calvet et al. 2017 [27] |
NA | 0.038 | Sarnaik et al. 2009 [74] | |
Apolipoprotein A1 | 0.96 | < 0.05 | Strouse et al. 2009 [75] |
Extracranial stenosis | 3.11 (1.10–8.85) | 0.033 | Bernaudin et al. 2015 [58] |
SEN β-globin haplotype | 2.53 (1.03–6.23) | 0.044 | Kinney et al. 1999 [72] |
VOC rate | 0.53 (0.30–0.95) | 0.034 | Kinney et al. 1999 [72] |
Acute anaemic event | 3.39 (1.01–11.34) | 0.048 | Bernaudin et al. 2015 [58] |
Seizure | 14.4 (1.5–141) | 0.023 | Kinney et al. 1999 [72] |