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Table 4 Multivariable logistic regression model predicting ASQ dimension result below the − 2SD cut-off for 235 toddlers included in the analysis by ZIKV exposure status

From: In utero Zika virus exposure and neurodevelopment at 24 months in toddlers normocephalic at birth: a cohort study

  Adjusted OR (95% CI) of ASQ dimension below − 2SD cut-off
Characteristic Communication P value Gross motor P value Fine motor P value Problem solving P value Personal-social P value
ZIKV exposure
 Exposed 0.26 (0.1–0.6) 0.004 0.71 (0.1–4.0) 0.70 0.47 (0.1–2.2) 0.33 1.73 (0.3–9.9) 0.54 0.63 (0.2–1.8) 0.40
 Unexposed 1   1   1   1   1  
Sex
 Male 1   1   1   1   1  
 Female 0.35 (0.1–0.9) 0.03 1.73 (0.3–8.8) 0.51 0.83 (0.2–3.7) 0.81 0.34 (0.1–1.5) 0.16 0.60 (0.2–1.7) 0.33
Education of mother
 Primary 1 0.71 1 0.87 1 0.64 1 0.52 1 0.10
 Secondary 0.68 (0.2–2.5)   0.82 (0.1–7.3)   0.34 (0.04–2.8)   0.28 (0.04–2.1)   1.16 (0.2–7.3)  
 Tertiary 0.57 (0.1–2.3)   0.39 (0.03–5.0)   0.32 (0.03–2.9)   0.81 (0.1–5.4)   1.53 (0.3–9.5)  
 Unknown 1.65 (0.3–9.4)   1.22 (0.1–25.8)   1.37 (0.1–19.7)   1.05 (0.1–12.6)   9.54 (1.3–69.6)  
Education of father
 Primary 1 0.55 1 0.75 1 0.36 1 0.17 1 0.11
 Secondary 0.47 (0.1–2.2)   1.35 (0.1–15.9)   1.05 (0.1–15.2)   0.66 (0.1–6.1)   0.57 (0.1–2.7)  
 Tertiary 0.33 (0.1–1.9)   0.57 (0.02–15.7)   0 (0)   0 (0)   0.24 (0.04–1.6)  
 Unknown 0.40 (0.1–1.5)   0.51 (0.05–4.9)   1.11 (0.1–13.4)   0.8 (0.1–5.6)   0.18 (0.04–0.9)  
Languages spoken in the household
 One 1   1   1   1 0.29 1 0.99
 More than one 2.15 (0.8–5.7) 0.12 0.64 (0.13–3.2) 0.58 0.39 (0.1–1.8) 0.23 2.4 (0.4–12.9)   1.01 (0.4–2.9)  
 Parity
 0 1 0.10 1 0.85 1 0.33 1 0.27 1 0.94
 1 0.59 (0.2–1.8)   0.95 (0.1–6.8)   0.39 (0.1–2.3)   0.19 (0.02–1.8)   0.92 (0.3–3.0)  
 2 1.15 (0.3–5.0)   2.25 (0.2–22.0)   0 (0)   0.77 (0.1–6.3)   0.58 (0.1–4.3)  
 3+ 3.22 (1.0–11.0)   0.67 (0.03–14.1)   0.43 (0.1–6.1)   1.60 (0.3–10.5)   1.14 (0.2–6.0)  
Birth weight
 Low birth weight 0.35 (0.1–2.5) 0.30 10.21 (1.7–61.3) 0.01 2.3 (0.2–30.1) 0.52 0 (0)   0.82 (0.1–6.4) 0.85
 Normal 1   1   1   1   1