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Table 2 Neurodevelopmental outcome at 12 months corrected age and 36 months chronological age

From: Early maternal care restores LINE-1 methylation and enhances neurodevelopment in preterm infants

 

Standard care

Early intervention

p value

12 months follow-up

n = 15

n = 17

 

 General quotient, mean ± SD

90.5 ± 3.3

93.9 ± 4.4

0.017^

 Locomotor, mean ± SD

96.3 ± 5.7

94.9 ± 9.8

0.894*

 Personal-social, mean ± SD

87.5 ± 4.6

93.9 ± 5.1

0.001^

 Hearing and language, mean ± SD

91.0 ± 4.2

94.8 ± 3.8

0.024*

 Eye and hand coordination, mean ± SD

89.5 ± 6.2

94.7 ± 4.8

0.014^

 Performance, mean ± SD

91.1 ± 3.9

94.8 ± 5.6

0.026*

36 months follow-up

n = 15

n = 14

 

 General quotient, mean ± SD

86.5 ± 4.7

90.7 ± 4.8

0.026^

 Locomotor, mean ± SD

91.3 ± 4.0

91.9 ± 5.5

0.744^

 Personal-social, mean ± SD

85.0 ± 5.3

89.8 ± 4.1

0.009*

 Hearing and language, mean ± SD

86.1 ± 7.4

92.3 ± 5.2

0.014^

 Eye and hand coordination, mean ± SD

86.8 ± 5.9

92.4 ± 4.7

0.009^

 Foundation of learninga, mean ± SD

89.0 ± 5.3

93.7 ± 3.4

0.008^

  1. Means ± standard deviations are shown. P values were obtained using t test (^) or Mann-Whitney U test (*). aThis subscale corresponds to “Performance” in GMDS-R