From: Early maternal care restores LINE-1 methylation and enhances neurodevelopment in preterm infants
Standard care | Early intervention | p value | |
---|---|---|---|
12 months follow-up | n = 15 | n = 17 | |
General quotient, mean ± SD | 90.5 ± 3.3 | 93.9 ± 4.4 | 0.017^ |
Locomotor, mean ± SD | 96.3 ± 5.7 | 94.9 ± 9.8 | 0.894* |
Personal-social, mean ± SD | 87.5 ± 4.6 | 93.9 ± 5.1 | 0.001^ |
Hearing and language, mean ± SD | 91.0 ± 4.2 | 94.8 ± 3.8 | 0.024* |
Eye and hand coordination, mean ± SD | 89.5 ± 6.2 | 94.7 ± 4.8 | 0.014^ |
Performance, mean ± SD | 91.1 ± 3.9 | 94.8 ± 5.6 | 0.026* |
36 months follow-up | n = 15 | n = 14 | |
General quotient, mean ± SD | 86.5 ± 4.7 | 90.7 ± 4.8 | 0.026^ |
Locomotor, mean ± SD | 91.3 ± 4.0 | 91.9 ± 5.5 | 0.744^ |
Personal-social, mean ± SD | 85.0 ± 5.3 | 89.8 ± 4.1 | 0.009* |
Hearing and language, mean ± SD | 86.1 ± 7.4 | 92.3 ± 5.2 | 0.014^ |
Eye and hand coordination, mean ± SD | 86.8 ± 5.9 | 92.4 ± 4.7 | 0.009^ |
Foundation of learninga, mean ± SD | 89.0 ± 5.3 | 93.7 ± 3.4 | 0.008^ |