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Table 1 Summary of clinical data

From: C-reactive protein as a potential biomarker for disease progression in dengue: a multi-country observational study

CharacteristicnOFI (N = 394)nAll dengue patients (N = 1117)nUncomplicated dengue (N = 836)nIntermediate dengue (N = 243)nSevere dengue (N = 38)
Country394 1117 836 243 38 
 Cambodia 0 (0.0) 99 (8.9) 69 (8.3) 20 (8.2) 10 (26.3)
 El Salvador 0 (0.0) 41 (3.7) 23 (2.8) 12 (4.9) 6 (15.8)
 Malaysia 0 (0.0) 117 (10.5) 88 (10.5) 26 (10.7) 3 (7.9)
 Vietnam 394 (100.0) 860 (77.0) 656 (78.5) 185 (76.1) 19 (50.0)
Age (year)39415 (8, 27)111715 (10, 25)83614 (10, 25)24317 (11, 26)3810 (8, 14)
Gender male, n (%)394241 (61.2)1117637 (57.0)836467 (55.9)243147 (60.5)3823 (60.5)
DOI at enrollment, n (%)394 1117 836 243 38 
 1 99 (25.1) 225 (20.1) 176 (21.1) 42 (17.3) 7 (18.4)
 2 162 (41.1) 555 (49.7) 425 (50.8) 117 (48.1) 13 (34.2)
 3 133 (33.8) 337 (30.2) 235 (28.1) 84 (34.6) 18 (47.4)
Serotype, n (%) 1049 782 231 36 
 DENV-1  435 (41.5) 314 (40.2) 101 (43.7) 20 (55.6)
 DENV-2  186 (17.7) 139 (17.8) 42 (18.2) 5 (13.9)
 DENV-3  105 (10.0) 76 (9.7) 26 (11.3) 3 (8.3)
 DENV-4  323 (30.8) 253 (32.4) 62 (26.8) 8 (22.2)
Serology, n (%) 1117 836 243 38 
 Probable primary  215 (19.2) 174 (20.8) 39 (16.0) 2 (5.3)
 Probable secondary  763 (68.3) 545 (65.2) 185 (76.1) 33 (86.8)
 Inconclusive  139 (12.4) 117 (14.0) 19 (7.8) 3 (7.9)
Used antibiotics1, n (%)392140 (35.7)111574 (6.6)83446 (5.5)24320 (8.2)388 (21.1)
DOI of starting antibiotic1394.0 (3.0, 5.0)744.0 (3.0, 5.8)464.0 (3.0, 5.0)204.0 (3.0, 6.0)86.5 (4.0, 8.0)
Length of fever (day)23445.0 (5.0, 6.0)9146.0 (5.0, 7.0)7086.0 (5.0, 7.0)1847.0 (6.0, 7.0)227.5 (6.0, 8.0)
Used any blood product3, n (%)3920 (0.0)11173 (0.3)8360 (0.0)2432 (0.8)381 (2.6)
Hospitalization, n (%)39476 (19.3)1117421 (37.7)836260 (31.1)243123 (50.6)3838 (100.0)
DOI when hospitalization764.0 (3.0, 5.0)4215.0 (4.0, 5.0)2604.0 (4.0, 5.0)1235.0 (4.0, 5.0)384.5 (4.0, 5.0)
Length of hospital stay (day)764.0 (4.0, 6.0)4204.0 (3.0, 5.0)2603.0 (2.0, 4.0)1234.0 (3.0, 5.0)375.0 (4.0, 6.0)
Clinical diagnosis of bacterial infection, n (%)394131 (33.2)111754 (4.8)83638 (4.5)24312 (4.9)384 (10.5)
 Used antibiotics4, n (%)131113 (86.3)5441 (75.9)3829 (76.3)129 (75.0)43 (75.0)
  1. Summary statistic is median (interquartile range) for numeric variables and absolute count (percentage) for categorical variables
  2. DOI day of illness, OFI other febrile illnesses
  3. 1There were 4 missing cases about the information of using antibiotic or not (2 in the OFI group and 2 in the uncomplicated dengue group)
  4. 2There were 253 cases with fever at the end of study follow-up; therefore, the time of defervescence was unknown
  5. 3There were 2 cases received platelet transfusion in the intermediate dengue group, and 1 case received whole blood transfusion in the severe dengue group
  6. 4Summary data of using antibiotics in each probable bacterial group