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Table 5 Sensitivity analyses of the IRRs of infection-related hospital admissions in month 3–6 after an antibiotic prescription (CPRD and SAIL)

From: The effectiveness of frequent antibiotic use in reducing the risk of infection-related hospital admissions: results from two large population-based cohorts

  Quintile of prior antibiotic use
 CPRDSAIL
LowestHighHighestHighHighest
SubgroupCohorts Adjusted IRR (95% CI)Adjusted IRR (95% CI)Adjusted IRR (95% CI)Adjusted IRR (95% CI)
Age < 18 yearsPropensity-matched (URTI, LRTI, UTI, otitis media or externa)Reference3.10 (2.24–4.29)5.14 (3.02–8.75)3.16 (2.65–3.76)3.69 (2.83–4.82)
Age 18–59 years Reference2.11 (1.61–2.75)2.53 (1.74–3.67)1.88 (1.46–2.42)2.43 (1.73–3.41)
Age 60+ years Reference1.52 (1.29–1.79)2.07 (1.74–2.48)1.29 (1.06–1.58)1.63 (1.28–2.07)
Calendar year 2000–2004 Reference1.51 (1.05–2.17)2.12 (1.33–3.40)1.36 (0.95–1.95)1.64 (1.07–2.52)
Calendar year 2005–2009 Reference1.74 (1.45–2.07)2.39 (1.89–3.03)2.09 (1.68–2.61)2.28 (1.73–3.00)
Calendar year 2010+ Reference1.89 (1.56–2.28)2.17 (1.66–2.84)2.31 (1.98–2.69)2.86 (2.31–3.54)
One randomly sampled record per patient (any age and calendar time) Reference2.07 (1.78–2.42)2.69 (2.22–3.26)2.19 (1.87–2.56)2.87 (2.28–3.61)
AllPropensity-matched (any or no coded indication)Reference1.57 (1.45–1.71)1.88 (1.70–2.08)1.82 (1.68–1.97)2.06 (1.87–2.27)
 Propensity-matched (any or no coded indication and no inpatient/outpatient referral in 1 year before)Reference1.70 (1.39–2.06)2.09 (1.60–2.73)1.91 (1.67–2.18)1.76 (1.50–2.06)
LRTIPropensity-matched (LRTI)Reference1.57 (1.21–2.04)1.95 (1.46–2.61)1.48 (1.17–1.87)2.36 (1.76–3.18)
URTIPropensity-matched (URTI)Reference2.47 (2.08–2.93)3.17 (2.60–3.86)1.85 (1.55–2.21)2.39 (1.87–3.05)
UTIPropensity-matched (UTI)Reference1.12 (0.87–1.55)1.28 (0.88–1.87)1.57 (1.10–2.25)1.65 (1.05–2.58)