Table 5 Sensitivity analyses of the IRRs of infection-related hospital admissions in month 3–6 after an antibiotic prescription (CPRD and SAIL)

Age < 18 years

Propensity-matched (URTI, LRTI, UTI, otitis media or externa)

Reference

3.10 (2.24–4.29)

5.14 (3.02–8.75)

3.16 (2.65–3.76)

3.69 (2.83–4.82)

Age 18–59 years

Reference

2.11 (1.61–2.75)

2.53 (1.74–3.67)

1.88 (1.46–2.42)

2.43 (1.73–3.41)

Age 60+ years

Reference

1.52 (1.29–1.79)

2.07 (1.74–2.48)

1.29 (1.06–1.58)

1.63 (1.28–2.07)

Calendar year 2000–2004

Reference

1.51 (1.05–2.17)

2.12 (1.33–3.40)

1.36 (0.95–1.95)

1.64 (1.07–2.52)

Calendar year 2005–2009

Reference

1.74 (1.45–2.07)

2.39 (1.89–3.03)

2.09 (1.68–2.61)

2.28 (1.73–3.00)

Calendar year 2010+

Reference

1.89 (1.56–2.28)

2.17 (1.66–2.84)

2.31 (1.98–2.69)

2.86 (2.31–3.54)

One randomly sampled record per patient (any age and calendar time)

Reference

2.07 (1.78–2.42)

2.69 (2.22–3.26)

2.19 (1.87–2.56)

2.87 (2.28–3.61)

All

Propensity-matched (any or no coded indication)

Reference

1.57 (1.45–1.71)

1.88 (1.70–2.08)

1.82 (1.68–1.97)

2.06 (1.87–2.27)

Propensity-matched (any or no coded indication and no inpatient/outpatient referral in 1 year before)

Reference

1.70 (1.39–2.06)

2.09 (1.60–2.73)

1.91 (1.67–2.18)

1.76 (1.50–2.06)

LRTI

Propensity-matched (LRTI)

Reference

1.57 (1.21–2.04)

1.95 (1.46–2.61)

1.48 (1.17–1.87)

2.36 (1.76–3.18)

URTI

Propensity-matched (URTI)

Reference

2.47 (2.08–2.93)

3.17 (2.60–3.86)

1.85 (1.55–2.21)

2.39 (1.87–3.05)

UTI

Propensity-matched (UTI)

Reference

1.12 (0.87–1.55)

1.28 (0.88–1.87)

1.57 (1.10–2.25)

1.65 (1.05–2.58)