Fig. 2

Model projection of additional symptomatic influenza cases and hospitalizations averted annually in California and Texas by increasing the number of high-risk patients who initiate treatment within 48 h of symptoms onset. Here, a proportion of high-risk patients who received antiviral treatment more than 48 h after symptom onset were assumed to receive treatment earlier. For the sensitivity analysis, we increased and decreased the effective vaccination coverage by 10% and 20%, respectively. a, c The total number of symptomatic cases averted. b, d The total number of hospitalizations averted