Fig. 4
Circus Manhattan plot of cross-trait meta-analysis. The first layer of the plot illustrates the chromosome position and the second layer illustrates the representative genes of significant loci. Genes in red are shared genes between two traits [a BF% and HF; b BF% and CAD] with single-trait P value < 0.05. The inside layer illustrates the significance level − log10 (P value) shared markers from cross-trait meta-analysis. The red dots indicate genome-wide significant (P < 5 × 10− 8). Genes at loci in close proximity were assigned one gene label separated by a slash. Asterisks represent the gene closest to index SNP. #: The P value of gene CDKN2B-AS1 (rs4977574) is 9.9 × 10−84 (out of range)