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Table 3 Comparison of serum DIDO1-, FOXJ2-, and CPSF2-Ab levels between HDs and patients with acute myocardial infarction (AMI) or diabetes mellitus (DM) examined by AlphaLISA

From: Serum anti-DIDO1, anti-CPSF2, and anti-FOXJ2 antibodies as predictive risk markers for acute ischemic stroke

Alpha analysis (antibody level) DIDO1-Ab FOXJ2-Ab CPSF2-Ab
HD Average 11,373 12,218 5571
SD 1939 6636 2390
Cutoff value 15,251 25,490 10,351
Positive no. 4 4 7
Positive (%) 3.1% 3.1% 5.5%
AMI Average 11,634 22,965 5343
SD 2405 16,329 3070
Positive no. 10 44 6
Positive (%) 7.8% 34.4% 4.7%
P (AMI vs HD) 0.342 < 0.0001 0.508
DM Average 11,199 21,718 7232
SD 2252 24,383 3798
Positive no. 7 29 17
Positive (%) 5.5% 22.7% 13.3%
P (DM vs HD) 0.508 < 0.0001 < 0.0001
  1. The antigens used were purified DIDO1-GST protein and synthetic peptides, bFOXJ2-426 and bCPSF2-607. The shown numbers are as described in Table 2; P values lower than 0.05 and positive rates higher than 10% are marked in bold. Box-whisker plots of the same results are shown in Fig. 3a, d, and g