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Table 5 Receiver operating characteristic (ROC) analysis

From: Serum anti-DIDO1, anti-CPSF2, and anti-FOXJ2 antibodies as predictive risk markers for acute ischemic stroke

  DIDO1-Ab vs TIA DIDO1-Ab vs AIS   
AUC 0.6767 0.6023   
95% CI 0.6001–0.7533 0.5367–0.6680   
Cutoff value 14,184 19,924   
Sensitivity (%) 77.9% 27.9%   
Specificity (%) 49.6% 91.9%   
P value < 0.0001 0.0033   
  DIDO1-Ab vs AMI DIDO1-Ab vs DM   
AUC 0.5163 0.5347   
95% CI 0.4454–0.5875 0.4638–0.6057   
Cutoff value 13,519 10,700   
Sensitivity (%) 22.7% 46.9%   
Specificity (%) 85.8% 63.8%   
P value 0.650 0.338   
  DIDO1-Ab vs type 1 CKD DIDO1-Ab vs type 2 CKD DIDO1-Ab vs type 3 CKD  
AUC 0.8665 0.8728 0.8227  
95% CI 0.8144 to 0.9186 0.8092 to 0.9364 0.7611 to 0.8843  
Cutoff value 3375 3511 3158  
Sensitivity (%) 93.1% 90.6% 91.9%  
Specificity (%) 69.1% 70.2% 63.1%  
P value < 0.0001 < 0.0001 < 0.0001  
  DIDO1pep-Ab vs TIA DIDO1pep-Ab vs AIS   
AUC 0.6503 0.6611   
95% CI 0.5751–0.7256 0.6138–0.7084   
Cutoff value 4662 8413   
Sensitivity (%) 87.9% 43.9%   
Specificity (%) 38.3% 81.9%   
P value 0.0003 < 0.0001   
  FOXJ2-Ab vs TIA FOXJ2-Ab vs AIS CPSF2-Ab vs TIA CPSF2-Ab vs AIS
AUC 0.6696 0.7006 0.6314 0.6369
95% CI 0.6066 to 0.7326 0.6626 to 0.7386 0.5631–0.6997 0.5970–0.6768
Cutoff value 8978 8920 2643 2644
Sensitivity (%) 60.9% 65.1% 54.4% 57.8%
Specificity (%) 66.0% 66.0% 67.7% 67.7%
P value < 0.0001 < 0.0001 0.0002 < 0.0001
  FOXJ2-Ab vs AMI FOXJ2-Ab vs DM CPSF2-Ab vs AMI CPSF2-Ab vs DM
AUC 0.7418 0.6584 0.5522 0.6464
95% CI 0.6813 to 0.8022 0.5922 to 0.7245 0.4817 to 0.6226 0.5792 to 0.7136
Cutoff value 14,437 20,978 5356 6145
Sensitivity (%) 68.0% 34.4% 63.3% 55.5%
Specificity (%) 71.1% 91.4% 49.2% 70.3%
P value < 0.0001 < 0.0001 0.149 < 0.0001
  FOXJ2-Ab vs type 1 CKD FOXJ2-Ab vs type 2 CKD FOXJ2-Ab vs type 3 CKD  
AUC 0.7812 0.8769 0.7151  
95% CI 0.7200 to 0.8424 0.8124 to 0.9413 0.6439 to 0.7862  
Cutoff value 1236 1391 1354  
Sensitivity (%) 83.5% 93.8% 69.9%  
Specificity (%) 59.5% 71.4% 69.1%  
P value < 0.0001 < 0.0001 < 0.0001  
  CPSF2-Ab vs Type-1 CKD CPSF2-Ab vsType-2 CKD CPSF2-Ab vsType-3 CKD  
AUC 0.5040 0.6387 0.5196  
95% CI 0.4262–0.5817 0.5274–0.7500 0.4395–0.5996  
Cutoff value 641.5 901 706  
Sensitivity (%) 11.7% 65.6% 29.3%  
Specificity (%) 93.9% 62.2% 80.5%  
P value 0.921 0.022 0.635  
  1. Area under the curve (AUC), 95% CI, cutoff value, sensitivity (%), specificity (%), and P value of the ROC analysis are shown. Purified GST-DIDO1 protein and synthetic peptides—bDIDO1-297 (DIDO1pep), bFOXJ2-426, and bCPSF2-607—were used as antigens. P values lower than 0.05 and AUCs higher than 0.7 are marked in bold