Skip to main content

Table 5 Receiver operating characteristic (ROC) analysis

From: Serum anti-DIDO1, anti-CPSF2, and anti-FOXJ2 antibodies as predictive risk markers for acute ischemic stroke

 

DIDO1-Ab vs TIA

DIDO1-Ab vs AIS

  

AUC

0.6767

0.6023

  

95% CI

0.6001–0.7533

0.5367–0.6680

  

Cutoff value

14,184

19,924

  

Sensitivity (%)

77.9%

27.9%

  

Specificity (%)

49.6%

91.9%

  

P value

< 0.0001

0.0033

  
 

DIDO1-Ab vs AMI

DIDO1-Ab vs DM

  

AUC

0.5163

0.5347

  

95% CI

0.4454–0.5875

0.4638–0.6057

  

Cutoff value

13,519

10,700

  

Sensitivity (%)

22.7%

46.9%

  

Specificity (%)

85.8%

63.8%

  

P value

0.650

0.338

  
 

DIDO1-Ab vs type 1 CKD

DIDO1-Ab vs type 2 CKD

DIDO1-Ab vs type 3 CKD

 

AUC

0.8665

0.8728

0.8227

 

95% CI

0.8144 to 0.9186

0.8092 to 0.9364

0.7611 to 0.8843

 

Cutoff value

3375

3511

3158

 

Sensitivity (%)

93.1%

90.6%

91.9%

 

Specificity (%)

69.1%

70.2%

63.1%

 

P value

< 0.0001

< 0.0001

< 0.0001

 
 

DIDO1pep-Ab vs TIA

DIDO1pep-Ab vs AIS

  

AUC

0.6503

0.6611

  

95% CI

0.5751–0.7256

0.6138–0.7084

  

Cutoff value

4662

8413

  

Sensitivity (%)

87.9%

43.9%

  

Specificity (%)

38.3%

81.9%

  

P value

0.0003

< 0.0001

  
 

FOXJ2-Ab vs TIA

FOXJ2-Ab vs AIS

CPSF2-Ab vs TIA

CPSF2-Ab vs AIS

AUC

0.6696

0.7006

0.6314

0.6369

95% CI

0.6066 to 0.7326

0.6626 to 0.7386

0.5631–0.6997

0.5970–0.6768

Cutoff value

8978

8920

2643

2644

Sensitivity (%)

60.9%

65.1%

54.4%

57.8%

Specificity (%)

66.0%

66.0%

67.7%

67.7%

P value

< 0.0001

< 0.0001

0.0002

< 0.0001

 

FOXJ2-Ab vs AMI

FOXJ2-Ab vs DM

CPSF2-Ab vs AMI

CPSF2-Ab vs DM

AUC

0.7418

0.6584

0.5522

0.6464

95% CI

0.6813 to 0.8022

0.5922 to 0.7245

0.4817 to 0.6226

0.5792 to 0.7136

Cutoff value

14,437

20,978

5356

6145

Sensitivity (%)

68.0%

34.4%

63.3%

55.5%

Specificity (%)

71.1%

91.4%

49.2%

70.3%

P value

< 0.0001

< 0.0001

0.149

< 0.0001

 

FOXJ2-Ab vs type 1 CKD

FOXJ2-Ab vs type 2 CKD

FOXJ2-Ab vs type 3 CKD

 

AUC

0.7812

0.8769

0.7151

 

95% CI

0.7200 to 0.8424

0.8124 to 0.9413

0.6439 to 0.7862

 

Cutoff value

1236

1391

1354

 

Sensitivity (%)

83.5%

93.8%

69.9%

 

Specificity (%)

59.5%

71.4%

69.1%

 

P value

< 0.0001

< 0.0001

< 0.0001

 
 

CPSF2-Ab vs Type-1 CKD

CPSF2-Ab vsType-2 CKD

CPSF2-Ab vsType-3 CKD

 

AUC

0.5040

0.6387

0.5196

 

95% CI

0.4262–0.5817

0.5274–0.7500

0.4395–0.5996

 

Cutoff value

641.5

901

706

 

Sensitivity (%)

11.7%

65.6%

29.3%

 

Specificity (%)

93.9%

62.2%

80.5%

 

P value

0.921

0.022

0.635

 
  1. Area under the curve (AUC), 95% CI, cutoff value, sensitivity (%), specificity (%), and P value of the ROC analysis are shown. Purified GST-DIDO1 protein and synthetic peptides—bDIDO1-297 (DIDO1pep), bFOXJ2-426, and bCPSF2-607—were used as antigens. P values lower than 0.05 and AUCs higher than 0.7 are marked in bold
Back to article page

BMC Medicine

ISSN: 1741-7015

Contact us