Serum anti-DIDO1, anti-CPSF2, and anti-FOXJ2 antibodies as predictive risk markers for acute ischemic stroke

Hiwasa, Takaki; Wang, Hao; Goto, Ken-ichiro; Mine, Seiichiro; Machida, Toshio; Kobayashi, Eiichi; Yoshida, Yoichi; Adachi, Akihiko; Matsutani, Tomoo; Sata, Mizuki; Yamagishi, Kazumasa; Iso, Hiroyasu; Sawada, Norie; Tsugane, Shoichiro; Kunimatsu, Mitoshi; Kamitsukasa, Ikuo; Mori, Masahiro; Sugimoto, Kazuo; Uzawa, Akiyuki; Muto, Mayumi; Kuwabara, Satoshi; Kobayashi, Yoshio; Ohno, Mikiko; Nishi, Eiichiro; Hattori, Akiko; Yamamoto, Masashi; Maezawa, Yoshiro; Kobayashi, Kazuki; Ishibashi, Ryoichi; Takemoto, Minoru; Yokote, Koutaro; Takizawa, Hirotaka; Kishimoto, Takashi; Matsushita, Kazuyuki; Kobayashi, Sohei; Nomura, Fumio; Arasawa, Takahiro; Kagaya, Akiko; Maruyama, Tetsuro; Matsubara, Hisahiro; Tomiita, Minako; Hamanaka, Shinsaku; Imai, Yushi; Nakagawa, Tomoo; Kato, Naoya; Terada, Jiro; Matsumura, Takuma; Katsumata, Yusuke; Naito, Akira; Tanabe, Nobuhiro; Sakao, Seiichiro; Tatsumi, Koichiro; Ito, Masaaki; Shiratori, Fumiaki; Sumazaki, Makoto; Yajima, Satoshi; Shimada, Hideaki; Shirouzu, Mikako; Yokoyama, Shigeyuki; Kudo, Takashi; Doi, Hirofumi; Iwase, Katsuro; Ashino, Hiromi; Li, Shu-Yang; Kubota, Masaaki; Tomiyoshi, Go; Shinmen, Natsuko; Nakamura, Rika; Kuroda, Hideyuki; Iwadate, Yasuo

doi:10.1186/s12916-021-02001-9

Table 7 Correlation analysis of serum antibody levels against synthetic bDIDO1, bCPSF2, and bFOXJ2 peptides with data on subjects in the Sawara Hospital cohort

From: Serum anti-DIDO1, anti-CPSF2, and anti-FOXJ2 antibodies as predictive risk markers for acute ischemic stroke

Parameter*	Number of XY pairs	DIDO1pep-Ab		FOXJ2pep-Ab		CPSF2pep-Ab
Parameter*	Number of XY pairs	r value**	P value	r value	P value	r value	P value
Age	851	0.2074	< 0.0001***	0.2688	< 0.0001	0.1657	< 0.0001
Height	844	− 0.1227	0.0004	− 0.1229	0.0003	− 0.0799	0.0202
Weight	848	− 0.1047	0.0023	− 0.1196	0.0005	− 0.0707	0.0396
BMI	843	− 0.0311	0.3679	− 0.0552	0.1098	− 0.0343	0.3197
max IMT	646	0.1908	< 0.0001	0.2717	< 0.0001	0.2161	< 0.0001
A/G	820	− 0.0303	0.3858	− 0.0484	0.1662	− 0.0906	0.0094
AST	848	0.0605	0.0782	0.0205	0.5523	− 0.0496	0.1490
ALT	847	0.0063	0.8545	− 0.0079	0.8177	− 0.0800	0.0199
ALP	786	0.0850	0.0172	0.0743	0.0374	0.0319	0.3716
LDH	822	0.0718	0.0395	0.0291	0.4046	− 0.0134	0.7017
tBil	830	− 0.0576	0.0972	− 0.0752	0.0304	− 0.1024	0.0031
CHE	646	− 0.0895	0.0230	− 0.1671	< 0.0001	− 0.0982	0.0125
γ-GTP	795	0.0334	0.3474	0.0240	0.4996	− 0.0028	0.9381
TP	823	− 0.0971	0.0053	− 0.1443	< 0.0001	− 0.1084	0.0018
Albumin	832	− 0.0757	0.0289	− 0.1294	0.0002	− 0.1358	< 0.0001
BUN	846	0.0179	0.6038	0.0431	0.2103	− 0.0381	0.2686
CRE	842	− 0.0090	0.7946	0.0472	0.1714	− 0.0341	0.3233
eGFR	758	0.0176	0.6284	− 0.0255	0.4835	0.0230	0.5282
UA	622	0.0336	0.4023	0.0255	0.5261	0.0050	0.9006
AMY	527	− 0.0780	0.0735	− 0.0422	0.3350	− 0.0391	0.3701
T-CHO	744	− 0.0520	0.1568	− 0.0604	0.0994	− 0.1207	0.0010
HDL-C	550	− 0.0458	0.2840	− 0.0521	0.2222	0.0553	0.1952
TG	589	0.0199	0.6303	0.0038	0.9274	− 0.0405	0.3261
Na	833	0.0200	0.5635	0.0233	0.5027	0.0005	0.9881
K	832	− 0.0275	0.4280	− 0.0091	0.7928	− 0.0072	0.8359
Cl	833	0.0056	0.8708	0.0470	0.1752	0.0269	0.4376
Ca	495	− 0.0210	0.6408	− 0.0815	0.0708	− 0.0405	0.3682
IP	388	− 0.0023	0.9639	− 0.0465	0.3618	0.0546	0.2836
Fe	400	− 0.0406	0.4185	− 0.0575	0.2526	− 0.0472	0.3465
CRP	617	0.1172	0.0035	0.0775	0.0552	0.1041	0.0096
LDL-C	440	− 0.0513	0.2831	− 0.0771	0.1071	− 0.1180	0.0133
WBC	846	0.1036	0.0026	0.0848	0.0138	0.0417	0.2262
RBC	846	− 0.0426	0.2155	− 0.0649	0.0596	− 0.0711	0.0386
HGB	846	− 0.0113	0.7420	− 0.0329	0.3406	− 0.0672	0.0508
HCT	846	− 0.0078	0.8214	− 0.0271	0.4317	− 0.0528	0.1249
MCV	846	0.0683	0.0472	0.0959	0.0053	0.0510	0.1387
MCH	846	0.0474	0.1681	0.0776	0.0242	0.0081	0.8136
MCHC	846	− 0.0149	0.6659	− 0.0253	0.4635	− 0.0617	0.0728
RDW	846	0.0489	0.1551	0.0449	0.1928	0.0529	0.1245
PLT	846	− 0.0047	0.8919	− 0.0443	0.1992	0.0128	0.7097
MPV	846	− 0.0201	0.5589	− 0.0637	0.0646	− 0.0012	0.9716
PCT	846	− 0.0030	0.9312	− 0.0568	0.0993	0.0188	0.5853
PDW	846	− 0.0151	0.6611	− 0.0587	0.0886	− 0.0109	0.7512
BS	783	0.0834	0.0195	0.0678	0.0581	0.0644	0.0718
HbA1c	655	− 0.0204	0.6031	− 0.0170	0.6644	− 0.0277	0.4789

*Subjects’ data used were age, height, weight, body mass index (BMI), maximum intima–media thickness (max IMT), albumin/globulin ratio (A/G), aspartate aminotransferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), total bilirubin (tBil), cholinesterase (CHE), γ-glutamyl transpeptidase (γ-GTP), total protein (TP), albumin, blood urea nitrogen (BUN), creatinine (CRE), estimated glomerular filtration rate (eGFR), uric acid (UA), amylase (AMY), total cholesterol (T-CHO), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), sodium (Na), potassium (K), chlorine (Cl), calcium (Ca), inorganic phosphate (IP), iron (Fe), C-reactive protein (CRP), low-density lipoprotein cholesterol (LDL-C), white blood cells (WBC), red blood cells (RBC), hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), MCH concentration (MCHC), red cell distribution width (RDW), platelets (PLT), mean platelet volume (MPV), procalcitonin (PCT), platelet distribution width (PDW), blood sugar (BS), and glycated hemoglobin (HbA1c)
**Correlation coefficients (r values) and P values obtained through Spearman’s correlation analysis are shown
***Significant correlations (P < 0.05) are marked in bold

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ISSN: 1741-7015

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