From: A phenome-wide association study of genetically mimicked statins
Trait | IVW | MR-Egger | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Both sexes | Men | Women | Both sexes | Men | Women | ||||||||||||||||
Beta | 95% CI | P value | Beta | 95% CI | P value | Beta | 95% CI | P value | Beta | 95% CI | P value | PIntercept | Beta | 95% CI | P value | PIntercept | Beta | 95% CI | P value | PIntercept | |
ApoB | 1.11 | 1.06 to 1.17 | <0.001 | 1.15 | 1.08 to 1.21 | <0.001 | 1.07 | 1.02 to 1.12 | <0.001 | 1.18 | 1.10 to 1.27 | <0.001 | 0.022 | 1.20 | 1.11 to 1.30 | <0.001 | 0.112 | 1.14 | 1.07 to 1.21 | <0.001 | 0.013 |
TC | 0.91 | 0.83 to 0.98 | <0.001 | 0.94 | 0.87 to 1.01 | <0.001 | 0.89 | 0.82 to 0.97 | <0.001 | 0.87 | 0.76 to 0.98 | <0.001 | 0.449 | 0.92 | 0.82 to 1.02 | <0.001 | 0.571 | 0.85 | 0.74 to 0.96 | <0.001 | 0.325 |
HbA1c | 0.00 | −0.09 to 0.09 | 0.979 | −0.02 | −0.13 to 0.09 | 0.738 | 0.01 | −0.07 to 0.10 | 0.791 | −0.07 | −0.21 to 0.08 | 0.358 | 0.236 | −0.09 | −0.25 to 0.07 | 0.257 | 0.214 | −0.04 | −0.17 to 0.09 | 0.536 | 0.310 |
Calcium | 0.04 | −0.03 to 0.11 | 0.230 | 0.03 | −0.05 to 0.12 | 0.483 | 0.04 | −0.01 to 0.10 | 0.133 | −0.08 | −0.17 to 0.02 | 0.126 | 0.002 | −0.10 | −0.22 to 0.02 | 0.089 | 0.002 | −0.05 | −0.14 to 0.03 | 0.229 | 0.004 |
SHBG | 0.04 | −0.06 to 0.13 | 0.444 | 0.02 | −0.11 to 0.15 | 0.750 | 0.05 | −0.05 to 0.14 | 0.338 | 0.03 | −0.11 to 0.18 | 0.652 | 0.958 | −0.01 | −0.20 to 0.17 | 0.886 | 0.619 | 0.06 | −0.09 to 0.21 | 0.435 | 0.817 |
BMR | −0.04 | −0.07 to −0.02 | 0.003 | −0.07 | −0.12 to −0.02 | 0.004 | −0.06 | −0.11 to −0.02 | 0.009 | −0.06 | −0.10 to −0.01 | 0.018 | 0.552 | −0.07 | −0.14 to 0.00 | 0.054 | 0.949 | −0.09 | −0.16 to −0.01 | 0.020 | 0.385 |
MPV | 0.01 | −0.06 to 0.08 | 0.782 | 0.00 | −0.08 to 0.08 | 0.974 | 0.01 | −0.06 to 0.08 | 0.779 | 0.04 | −0.08 to 0.15 | 0.541 | 0.570 | −0.01 | −0.12 to 0.11 | 0.930 | 0.880 | 0.05 | −0.06 to 0.17 | 0.361 | 0.341 |
Platelet count | −0.06 | −0.17 to 0.04 | 0.247 | −0.07 | −0.19 to 0.05 | 0.262 | −0.06 | −0.16 to 0.05 | 0.290 | −0.07 | −0.24 to 0.10 | 0.405 | 0.907 | −0.05 | −0.23 to 0.13 | 0.574 | 0.780 | −0.08 | 0.24 to 0.09 | 0.372 | 0.768 |
Platelet crit | −0.07 | −0.18 to 0.04 | 0.234 | −0.08 | −0.20 to 0.04 | 0.202 | −0.06 | −0.17 to 0.05 | 0.298 | −0.06 | −0.23 to 0.11 | 0.485 | 0.932 | −0.06 | −0.24 to 0.12 | 0.493 | 0.798 | −0.05 | −0.23 to 0.12 | 0.538 | 0.961 |
BMI | −0.04 | −0.08 to −0.01 | 0.016 | −0.04 | −0.08 to 0.00 | 0.047 | −0.05 | −0.08 to −0.01 | 0.009 | −0.07 | −0.13 to −0.02 | 0.006 | 0.122 | −0.08 | −0.14 to −0.02 | 0.011 | 0.099 | −0.06 | −0.11 to −0.01 | 0.016 | 0.406 |
Weight | −0.06 | −0.09 to −0.02 | 0.002 | −0.06 | −0.11 to −0.02 | 0.004 | −0.07 | −0.12 to −0.03 | 0.002 | −0.07 | −0.13 to −0.02 | 0.012 | 0.456 | −0.09 | −0.16 to −0.03 | 0.007 | 0.248 | −0.07 | −0.14 to −0.01 | 0.027 | 0.924 |
Hip circumference | −0.04 | −0.09 to 0.00 | 0.030 | −0.05 | −0.09 to −0.01 | 0.017 | −0.04 | −0.08 to 0.01 | 0.102 | −0.05 | −0.12 to 0.01 | 0.101 | 0.747 | −0.07 | −0.13 to 0.00 | 0.040 | 0.475 | −0.03 | −0.1 to 0.03 | 0.321 | 0.867 |
Waist circumference | −0.05 | −0.07 to −0.02 | 0.001 | −0.05 | −0.08 to −0.01 | 0.009 | −0.06 | −0.09 to −0.02 | 0.002 | −0.08 | −0.12 to −0.04 | <0.001 | 0.038 | −0.10 | −0.15 to −0.04 | <0.001 | 0.016 | −0.07 | −0.12 to −0.02 | 0.010 | 0.535 |