A phenome-wide association study of genetically mimicked statins

Li, Shun; Schooling, C. M.

doi:10.1186/s12916-021-02013-5

Table 2 Sex-specific MR estimates of genetically predicted LDL-c on continuous phenotypes strongly associated with rs12916 (excluding some body composition traits)

From: A phenome-wide association study of genetically mimicked statins

Trait	IVW									MR-Egger
	Both sexes			Men			Women			Both sexes				Men				Women
	Beta	95% CI	P value	Beta	95% CI	P value	Beta	95% CI	P value	Beta	95% CI	P value	P_Intercept	Beta	95% CI	P value	P_Intercept	Beta	95% CI	P value	P_Intercept
ApoB	1.11	1.06 to 1.17	<0.001	1.15	1.08 to 1.21	<0.001	1.07	1.02 to 1.12	<0.001	1.18	1.10 to 1.27	<0.001	0.022	1.20	1.11 to 1.30	<0.001	0.112	1.14	1.07 to 1.21	<0.001	0.013
TC	0.91	0.83 to 0.98	<0.001	0.94	0.87 to 1.01	<0.001	0.89	0.82 to 0.97	<0.001	0.87	0.76 to 0.98	<0.001	0.449	0.92	0.82 to 1.02	<0.001	0.571	0.85	0.74 to 0.96	<0.001	0.325
HbA1c	0.00	−0.09 to 0.09	0.979	−0.02	−0.13 to 0.09	0.738	0.01	−0.07 to 0.10	0.791	−0.07	−0.21 to 0.08	0.358	0.236	−0.09	−0.25 to 0.07	0.257	0.214	−0.04	−0.17 to 0.09	0.536	0.310
Calcium	0.04	−0.03 to 0.11	0.230	0.03	−0.05 to 0.12	0.483	0.04	−0.01 to 0.10	0.133	−0.08	−0.17 to 0.02	0.126	0.002	−0.10	−0.22 to 0.02	0.089	0.002	−0.05	−0.14 to 0.03	0.229	0.004
SHBG	0.04	−0.06 to 0.13	0.444	0.02	−0.11 to 0.15	0.750	0.05	−0.05 to 0.14	0.338	0.03	−0.11 to 0.18	0.652	0.958	−0.01	−0.20 to 0.17	0.886	0.619	0.06	−0.09 to 0.21	0.435	0.817
BMR	−0.04	−0.07 to −0.02	0.003	−0.07	−0.12 to −0.02	0.004	−0.06	−0.11 to −0.02	0.009	−0.06	−0.10 to −0.01	0.018	0.552	−0.07	−0.14 to 0.00	0.054	0.949	−0.09	−0.16 to −0.01	0.020	0.385
MPV	0.01	−0.06 to 0.08	0.782	0.00	−0.08 to 0.08	0.974	0.01	−0.06 to 0.08	0.779	0.04	−0.08 to 0.15	0.541	0.570	−0.01	−0.12 to 0.11	0.930	0.880	0.05	−0.06 to 0.17	0.361	0.341
Platelet count	−0.06	−0.17 to 0.04	0.247	−0.07	−0.19 to 0.05	0.262	−0.06	−0.16 to 0.05	0.290	−0.07	−0.24 to 0.10	0.405	0.907	−0.05	−0.23 to 0.13	0.574	0.780	−0.08	0.24 to 0.09	0.372	0.768
Platelet crit	−0.07	−0.18 to 0.04	0.234	−0.08	−0.20 to 0.04	0.202	−0.06	−0.17 to 0.05	0.298	−0.06	−0.23 to 0.11	0.485	0.932	−0.06	−0.24 to 0.12	0.493	0.798	−0.05	−0.23 to 0.12	0.538	0.961
BMI	−0.04	−0.08 to −0.01	0.016	−0.04	−0.08 to 0.00	0.047	−0.05	−0.08 to −0.01	0.009	−0.07	−0.13 to −0.02	0.006	0.122	−0.08	−0.14 to −0.02	0.011	0.099	−0.06	−0.11 to −0.01	0.016	0.406
Weight	−0.06	−0.09 to −0.02	0.002	−0.06	−0.11 to −0.02	0.004	−0.07	−0.12 to −0.03	0.002	−0.07	−0.13 to −0.02	0.012	0.456	−0.09	−0.16 to −0.03	0.007	0.248	−0.07	−0.14 to −0.01	0.027	0.924
Hip circumference	−0.04	−0.09 to 0.00	0.030	−0.05	−0.09 to −0.01	0.017	−0.04	−0.08 to 0.01	0.102	−0.05	−0.12 to 0.01	0.101	0.747	−0.07	−0.13 to 0.00	0.040	0.475	−0.03	−0.1 to 0.03	0.321	0.867
Waist circumference	−0.05	−0.07 to −0.02	0.001	−0.05	−0.08 to −0.01	0.009	−0.06	−0.09 to −0.02	0.002	−0.08	−0.12 to −0.04	<0.001	0.038	−0.10	−0.15 to −0.04	<0.001	0.016	−0.07	−0.12 to −0.02	0.010	0.535

Back to article page

ISSN: 1741-7015

Contact us

Submission enquiries: bmcmedicineeditorial@biomedcentral.com
General enquiries: info@biomedcentral.com

BMC Medicine

Contact us