Skip to main content

Table 2 Sex-specific MR estimates of genetically predicted LDL-c on continuous phenotypes strongly associated with rs12916 (excluding some body composition traits)

From: A phenome-wide association study of genetically mimicked statins

Trait IVW MR-Egger
Both sexes Men Women Both sexes Men Women
Beta 95% CI P value Beta 95% CI P value Beta 95% CI P value Beta 95% CI P value PIntercept Beta 95% CI P value PIntercept Beta 95% CI P value PIntercept
ApoB 1.11 1.06 to 1.17 <0.001 1.15 1.08 to 1.21 <0.001 1.07 1.02 to 1.12 <0.001 1.18 1.10 to 1.27 <0.001 0.022 1.20 1.11 to 1.30 <0.001 0.112 1.14 1.07 to 1.21 <0.001 0.013
TC 0.91 0.83 to 0.98 <0.001 0.94 0.87 to 1.01 <0.001 0.89 0.82 to 0.97 <0.001 0.87 0.76 to 0.98 <0.001 0.449 0.92 0.82 to 1.02 <0.001 0.571 0.85 0.74 to 0.96 <0.001 0.325
HbA1c 0.00 −0.09 to 0.09 0.979 −0.02 −0.13 to 0.09 0.738 0.01 −0.07 to 0.10 0.791 −0.07 −0.21 to 0.08 0.358 0.236 −0.09 −0.25 to 0.07 0.257 0.214 −0.04 −0.17 to 0.09 0.536 0.310
Calcium 0.04 −0.03 to 0.11 0.230 0.03 −0.05 to 0.12 0.483 0.04 −0.01 to 0.10 0.133 −0.08 −0.17 to 0.02 0.126 0.002 −0.10 −0.22 to 0.02 0.089 0.002 −0.05 −0.14 to 0.03 0.229 0.004
SHBG 0.04 −0.06 to 0.13 0.444 0.02 −0.11 to 0.15 0.750 0.05 −0.05 to 0.14 0.338 0.03 −0.11 to 0.18 0.652 0.958 −0.01 −0.20 to 0.17 0.886 0.619 0.06 −0.09 to 0.21 0.435 0.817
BMR −0.04 −0.07 to −0.02 0.003 −0.07 −0.12 to −0.02 0.004 −0.06 −0.11 to −0.02 0.009 −0.06 −0.10 to −0.01 0.018 0.552 −0.07 −0.14 to 0.00 0.054 0.949 −0.09 −0.16 to −0.01 0.020 0.385
MPV 0.01 −0.06 to 0.08 0.782 0.00 −0.08 to 0.08 0.974 0.01 −0.06 to 0.08 0.779 0.04 −0.08 to 0.15 0.541 0.570 −0.01 −0.12 to 0.11 0.930 0.880 0.05 −0.06 to 0.17 0.361 0.341
Platelet count −0.06 −0.17 to 0.04 0.247 −0.07 −0.19 to 0.05 0.262 −0.06 −0.16 to 0.05 0.290 −0.07 −0.24 to 0.10 0.405 0.907 −0.05 −0.23 to 0.13 0.574 0.780 −0.08 0.24 to 0.09 0.372 0.768
Platelet crit −0.07 −0.18 to 0.04 0.234 −0.08 −0.20 to 0.04 0.202 −0.06 −0.17 to 0.05 0.298 −0.06 −0.23 to 0.11 0.485 0.932 −0.06 −0.24 to 0.12 0.493 0.798 −0.05 −0.23 to 0.12 0.538 0.961
BMI −0.04 −0.08 to −0.01 0.016 −0.04 −0.08 to 0.00 0.047 −0.05 −0.08 to −0.01 0.009 −0.07 −0.13 to −0.02 0.006 0.122 −0.08 −0.14 to −0.02 0.011 0.099 −0.06 −0.11 to −0.01 0.016 0.406
Weight −0.06 −0.09 to −0.02 0.002 −0.06 −0.11 to −0.02 0.004 −0.07 −0.12 to −0.03 0.002 −0.07 −0.13 to −0.02 0.012 0.456 −0.09 −0.16 to −0.03 0.007 0.248 −0.07 −0.14 to −0.01 0.027 0.924
Hip circumference −0.04 −0.09 to 0.00 0.030 −0.05 −0.09 to −0.01 0.017 −0.04 −0.08 to 0.01 0.102 −0.05 −0.12 to 0.01 0.101 0.747 −0.07 −0.13 to 0.00 0.040 0.475 −0.03 −0.1 to 0.03 0.321 0.867
Waist circumference −0.05 −0.07 to −0.02 0.001 −0.05 −0.08 to −0.01 0.009 −0.06 −0.09 to −0.02 0.002 −0.08 −0.12 to −0.04 <0.001 0.038 −0.10 −0.15 to −0.04 <0.001 0.016 −0.07 −0.12 to −0.02 0.010 0.535