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Table 2 Rate ratios for severe COVID-19 in those not resident in care homes

From: Relation of severe COVID-19 in Scotland to transmission-related factors and risk conditions eligible for shielding support: REACT-SCOT case-control study

    Univariate Multivariable
  Controls (86,902) Cases (7217) Rate ratio (95% CI) p-value Rate ratio (95% CI) p-value
No risk condition 45,354 (52%) 1897 (26%)   .   .
Moderate risk condition 33,909 (39%) 3702 (51%) 3.20 (3.01, 3.41) <0.001 2.67 (2.50, 2.85) <0.001
Shielding eligibility category
Solid organ transplant 112 (0%) 59 (1%) 13.4 (9.6, 18.8) <0.001 7.0 (4.6, 10.4) <0.001
Specific cancers 907 (1%) 240 (3%) 7.9 (6.8, 9.3) <0.001 3.47 (2.87, 4.19) <0.001
Severe respiratory 3751 (4%) 733 (10%) 5.8 (5.2, 6.4) <0.001 4.32 (3.87, 4.83) <0.001
Rare diseases 341 (0%) 69 (1%) 7.0 (5.3, 9.3) <0.001 4.68 (3.37, 6.49) <0.001
On immunosuppressants 742 (1%) 126 (2%) 4.61 (3.76, 5.65) <0.001 3.26 (2.59, 4.10) <0.001
Additional conditions 1786 (2%) 391 (5%) 6.6 (5.8, 7.5) <0.001 4.31 (3.72, 5.00) <0.001
At least one child under 5 1759 (2%) 150 (2%) 0.87 (0.73, 1.04) 0.1 0.73 (0.60, 0.89) 0.002
Number of school age children in household
0 school age 80,885 (93%) 6685 (93%)   .   .
1 school age 1749 (2%) 93 (1%) 0.54 (0.43, 0.67) <0.001 0.76 (0.60, 0.96) 0.02
2 or more 4268 (5%) 439 (6%) 1.06 (0.95, 1.19) 0.3 0.71 (0.62, 0.80) <0.001
Number of adults in household
1 adult 62,011 (72%) 4259 (59%)   .   .
2 adults 19,190 (22%) 1951 (27%) 1.57 (1.48, 1.67) <0.001 1.80 (1.68, 1.92) <0.001
3 to 4 4611 (5%) 769 (11%) 2.50 (2.28, 2.74) <0.001 3.19 (2.87, 3.54) <0.001
5 to 9 326 (0%) 85 (1%) 3.98 (3.10, 5.11) <0.001 5.8 (4.3, 7.7) <0.001
10 or more 247 (0%) 102 (1%) 10.6 (7.6, 14.6) <0.001 11.4 (8.0, 16.2) <0.001
SIMD quintile
1 - most deprived 21,388 (25%) 2162 (30%)   .   .
2 19,072 (22%) 1761 (24%) 0.91 (0.85, 0.98) 0.01 0.95 (0.88, 1.03) 0.3
3 15,399 (18%) 1264 (18%) 0.76 (0.70, 0.82) <0.001 0.84 (0.76, 0.92) <0.001
4 14,870 (17%) 1079 (15%) 0.65 (0.59, 0.70) <0.001 0.72 (0.65, 0.79) <0.001
5 - least deprived 16,084 (19%) 944 (13%) 0.53 (0.48, 0.58) <0.001 0.60 (0.53, 0.66) <0.001
Occupation
Other / undetermined 84,672 (98%) 6962 (97%)   .   .
Teacher 336 (0%) 11 (0%) 0.35 (0.19, 0.64) <0.001 0.42 (0.22, 0.81) 0.01
Health care, not PF / undetermined 826 (1%) 87 (1%) 1.18 (0.94, 1.47) 0.2 1.20 (0.94, 1.53) 0.2
Health care PF 846 (1%) 145 (2%) 1.80 (1.50, 2.16) <0.001 1.86 (1.52, 2.27) <0.001
Recent hospital visit/stay 3565 (4%) 2415 (33%) 12.3 (11.5, 13.2) <0.001 10.2 (9.5, 11.0) <0.001
  1. Severe COVID-19 is defined by entry to critical care or fatal outcome
  2. Percentages are column percentages for each variable
  3. PF, patient-facing
  4. Rate ratios are from conditional logistic regression models with cases and controls matched for age, sex and general care practice
  5. Univariate rate ratios are for models with a single covariate
  6. Multivariable rate ratios are for a model including all covariates shown in the table