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Table 2 Rate ratios for severe COVID-19 in those not resident in care homes

From: Relation of severe COVID-19 in Scotland to transmission-related factors and risk conditions eligible for shielding support: REACT-SCOT case-control study

   

Univariate

Multivariable

 

Controls (86,902)

Cases (7217)

Rate ratio (95% CI)

p-value

Rate ratio (95% CI)

p-value

No risk condition

45,354 (52%)

1897 (26%)

 

.

 

.

Moderate risk condition

33,909 (39%)

3702 (51%)

3.20 (3.01, 3.41)

<0.001

2.67 (2.50, 2.85)

<0.001

Shielding eligibility category

Solid organ transplant

112 (0%)

59 (1%)

13.4 (9.6, 18.8)

<0.001

7.0 (4.6, 10.4)

<0.001

Specific cancers

907 (1%)

240 (3%)

7.9 (6.8, 9.3)

<0.001

3.47 (2.87, 4.19)

<0.001

Severe respiratory

3751 (4%)

733 (10%)

5.8 (5.2, 6.4)

<0.001

4.32 (3.87, 4.83)

<0.001

Rare diseases

341 (0%)

69 (1%)

7.0 (5.3, 9.3)

<0.001

4.68 (3.37, 6.49)

<0.001

On immunosuppressants

742 (1%)

126 (2%)

4.61 (3.76, 5.65)

<0.001

3.26 (2.59, 4.10)

<0.001

Additional conditions

1786 (2%)

391 (5%)

6.6 (5.8, 7.5)

<0.001

4.31 (3.72, 5.00)

<0.001

At least one child under 5

1759 (2%)

150 (2%)

0.87 (0.73, 1.04)

0.1

0.73 (0.60, 0.89)

0.002

Number of school age children in household

0 school age

80,885 (93%)

6685 (93%)

 

.

 

.

1 school age

1749 (2%)

93 (1%)

0.54 (0.43, 0.67)

<0.001

0.76 (0.60, 0.96)

0.02

2 or more

4268 (5%)

439 (6%)

1.06 (0.95, 1.19)

0.3

0.71 (0.62, 0.80)

<0.001

Number of adults in household

1 adult

62,011 (72%)

4259 (59%)

 

.

 

.

2 adults

19,190 (22%)

1951 (27%)

1.57 (1.48, 1.67)

<0.001

1.80 (1.68, 1.92)

<0.001

3 to 4

4611 (5%)

769 (11%)

2.50 (2.28, 2.74)

<0.001

3.19 (2.87, 3.54)

<0.001

5 to 9

326 (0%)

85 (1%)

3.98 (3.10, 5.11)

<0.001

5.8 (4.3, 7.7)

<0.001

10 or more

247 (0%)

102 (1%)

10.6 (7.6, 14.6)

<0.001

11.4 (8.0, 16.2)

<0.001

SIMD quintile

1 - most deprived

21,388 (25%)

2162 (30%)

 

.

 

.

2

19,072 (22%)

1761 (24%)

0.91 (0.85, 0.98)

0.01

0.95 (0.88, 1.03)

0.3

3

15,399 (18%)

1264 (18%)

0.76 (0.70, 0.82)

<0.001

0.84 (0.76, 0.92)

<0.001

4

14,870 (17%)

1079 (15%)

0.65 (0.59, 0.70)

<0.001

0.72 (0.65, 0.79)

<0.001

5 - least deprived

16,084 (19%)

944 (13%)

0.53 (0.48, 0.58)

<0.001

0.60 (0.53, 0.66)

<0.001

Occupation

Other / undetermined

84,672 (98%)

6962 (97%)

 

.

 

.

Teacher

336 (0%)

11 (0%)

0.35 (0.19, 0.64)

<0.001

0.42 (0.22, 0.81)

0.01

Health care, not PF / undetermined

826 (1%)

87 (1%)

1.18 (0.94, 1.47)

0.2

1.20 (0.94, 1.53)

0.2

Health care PF

846 (1%)

145 (2%)

1.80 (1.50, 2.16)

<0.001

1.86 (1.52, 2.27)

<0.001

Recent hospital visit/stay

3565 (4%)

2415 (33%)

12.3 (11.5, 13.2)

<0.001

10.2 (9.5, 11.0)

<0.001

  1. Severe COVID-19 is defined by entry to critical care or fatal outcome
  2. Percentages are column percentages for each variable
  3. PF, patient-facing
  4. Rate ratios are from conditional logistic regression models with cases and controls matched for age, sex and general care practice
  5. Univariate rate ratios are for models with a single covariate
  6. Multivariable rate ratios are for a model including all covariates shown in the table