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Table 2 Hazard ratios (95%CIs) of cardiovascular events with quartiles of FEV1 and FVC decline stratified by predefined subgroups

From: Longitudinal change in lung function and subsequent risks of cardiovascular events: evidence from four prospective cohort studies

 

Q1

Q2

Q3

Q4

P for interaction

FEV1 decline

 Age, years

  < 60

1.36 (1.10, 1.67)

1.25 (1.01, 1.56)

0.86 (0.68, 1.08)

Reference

< 0.001

  ≥ 60

1.23 (1.07, 1.42)

1.24 (1.08, 1.43)

1.12 (0.97, 1.30)

Reference

 

 Sex

  Women

1.20 (1.03, 1.41)

1.21 (1.04, 1.40)

0.98 (0.84, 1.14)

Reference

0.50

  Men

1.49 (1.25, 1.77)

1.41 (1.18, 1.70)

1.17 (0.97, 1.42)

Reference

 

 Race

  Non-white

1.61 (1.21, 2.14)

1.07 (0.74, 1.54)

1.21 (0.86, 1.71)

Reference

0.95

  White

1.30 (1.14, 1.47)

1.32 (1.17, 1.50)

1.06 (0.93, 1.21)

Reference

 

 Baseline BMI

  Normal

1.34 (1.11, 1.63)

1.14 (0.94, 1.38)

1.03 (0.84, 1.26)

Reference

0.85

  Overweight

1.25 (1.04, 1.51)

1.37 (1.14, 1.65)

1.03 (0.85, 1.25)

Reference

 

  Obese

1.39 (1.10, 1.75)

1.37 (1.08, 1.74)

1.19 (0.93, 1.53)

Reference

 

 Smoking status

  Never

1.23 (1.02, 1.47)

1.19 (1.00, 1.42)

0.98 (0.81, 1.18)

Reference

0.33

  Former

1.69 (1.29, 2.20)

1.65 (1.28, 2.12)

1.33 (1.03, 1.71)

Reference

 

  Current

1.28 (1.06, 1.54)

1.24 (1.01, 1.52)

1.00 (0.80, 1.24)

Reference

 

FVC decline

 Age, years

  < 60

1.64 (1.31, 2.05)

1.34 (1.08, 1.67)

1.18 (0.96, 1.46)

Reference

< 0.001

  ≥ 60

1.13 (0.98, 1.30)

1.03 (0.90, 1.19)

0.98 (0.84, 1.14)

Reference

 

 Sex

  Women

1.25 (1.07, 1.47)

1.09 (0.94, 1.28)

1.01 (0.86, 1.18)

Reference

0.50

  Men

1.32 (1.10, 1.58)

1.22 (1.01, 1.46)

1.09 (0.90, 1.31)

Reference

 

 Race

  Non-white

1.51 (1.10, 2.08)

1.15 (0.79, 1.67)

1.02 (0.70, 1.48)

Reference

0.95

  White

1.26 (1.11, 1.43)

1.16 (1.03, 1.32)

1.06 (0.93, 1.21)

Reference

 

 Baseline BMI

  Normal

1.28 (1.06, 1.56)

1.10 (0.91, 1.33)

1.08 (0.89, 1.31)

Reference

0.85

  Overweight

1.16 (0.96, 1.39)

1.02 (0.84, 1.23)

0.96 (0.79, 1.17)

Reference

 

  Obese

1.40 (1.09, 1.79)

1.50 (1.16, 1.93)

1.17 (0.90, 1.51)

Reference

 

 Smoking status

  Never

1.28 (1.06, 1.54)

1.20 (1.00, 1.44)

1.25 (1.04, 1.51)

Reference

0.33

  Former

1.24 (0.94, 1.63)

1.15 (0.87, 1.53)

1.01 (0.75, 1.36)

Reference

 

  Current

1.36 (1.13, 1.63)

1.10 (0.90, 1.34)

0.87 (0.73, 1.08)

Reference

 
  1. Adjusted model: adjusted for age, sex, race, education level, marital status, history of hypertension, diabetes, coronary heart disease, heart failure, chronic obstructive pulmonary disease, smoking status, current alcoholic use, physical activity, body mass index, fasting serum glucose, total cholesterol, high-density lipoprotein cholesterol, triglycerides, and low-density lipoprotein cholesterol
  2. FEV1 forced expiratory volume in one second, FVC forced vital capacity
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BMC Medicine

ISSN: 1741-7015

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