Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study

Table 1 Number of cancer cases and controls and statistical power in Mendelian randomization study on association of circulating vitamin C concentration with risk of site-specific cancers

Cancer type	Study/Consortium	Cases	Controls	Minimum detectable OR (R²=0.0187)
Lung (bronchus) cancer	UK Biobank	2,120	454,228	0.55/1.45
Prostate cancer		5,796	203,012	0.75/1.25
Breast cancer		10,892	236,648	0.80/1.21
Colon cancer		3,221	453,127	0.64/1.36
Rectal cancer		2,202	454,146	0.56/1.44
Lung cancer	ILCCO
Overall		11,348	15,861	0.77/1.28
Adenocarcinoma		3,442	14,894	0.64/1.42
Squamous cell carcinoma		3,275	15,038	0.63/1.42
Prostate cancer	PRACTICAL
Overall		79,148	61,106	0.89/1.12
Breast cancer	BCAC
Overall		133,384	113,789	0.92/1.09
ER-positive		69,501	105,974	0.90/1.11
ER-negative		21,468	105,974	0.85/1.16

ILCCO International Lung Cancer Consortium, PRACTICAL the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome, BCAC the Breast Cancer Association Consortium, OCAC the Ovarian Cancer Association Consortium

ISSN: 1741-7015