Oral vitamin D supplementation induces transcriptomic changes in rectal mucosa that are linked to anti-tumour effects

Table 1 Baseline characteristics, sampling variables and vitamin D status in included participants

	PHASE 1 Correlative dataset	PHASE 2 Intervention dataset
N	191	50
Age (median, range)	63 (24-89) years	66 (24-88) years
Gender (male)	101 (53%)	26 (52%)
Diagnosis
Pre-operative; colorectal cancer*	57	1
None (healthy)	63	20
Past medical history of CRC*	23	21
Minor anorectal pathology, no CRC^†	45	7
Abdominal tumour (not colorectal)	3	1
Sampled under general anaesthetic	89	3
Median 25-OHD –Baseline	40 (IQR 37) nmol/l	36 (IQR 31) nmol/l
Median 25-OHD –After supplementation	NA	89 (IQR 33.5) nmol/l

Ethnic background for Phase 1 participants were as follows: 183 European, 2 American, 3 African, 3 Asian. * Pre-operative patients had not undergone any neo-adjuvant chemo/radiotherapy at time of sampling. Patients with past history of CRC were previously treated with curative resection +/- adjuvant chemotherapy and no evidence of recurrence at time of recruitment. No significant differences in gene expression were identified according to participant diagnosis. † Full diagnosis list given in Additional file 3: Table S1

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