Table 3 Ratio of risks, odds, difference or means of secondary efficacy outcomes and harm outcomes across the three sources of data (clinical study report, journal publication and registry report)

  Time to relapse

ROR = 1.43 (0.31, 6.48)

ROR = 1.73 (0.39, 7.65)

ROR = 1.21 (0.56, 2.61)

  YMRS

ROM = − 1.83 (− 4.76, 1.10)

ROM = − 2.38 (− 4.64, 0.12)

ROM = − 2.38 (− 4.64, 0.12)

  CGI-S

ROM = − 0.56 (− 3.38, 2.26)

NA

NA

  TEAEs

RRR = 0.97 (0.83, 1.14)

RRR = 1.03 (0.86, 1.23)

RRR = 1.06 (0.84, 1.33)

  SAEs

RRR = 0.70 (0.14, 3.42)

RRR = 1.48 (0.64, 3.45)

RRR = 2.13 (0.37, 12.3)

  Discontinuation due to AEs

RRR = 1.14 (0.63, 2.05)

RRR = 0.65 (0.16, 2.67)

RRR = 0.57 (0.14, 2.42)

  Death

NA

NA

NA

  Time to relapse

ROR = 3.63 (0.33, 39.44)

ROR = 0.31 (0.03, 3.84)

ROR = 0.09 (0.03, 0.27)

  YMRS

ROM = 0.96 (− 1.73, 3.65)

ROM = − 0.28 (− 1.93, 1.37)

ROM = − 1.24 (− 4.16, 1.68)

  CGI-S

ROM = 2 (− 1.13, 5.13)

ROM = − 0.46 (− 1.83, 0.91)

ROM = − 2.46 (− 5.52, 0.60)

  TEAEs

RRR = 1 (0.91, 1.10)

RRR = 0.86 (0.71, 1.03)

RRR = 0.86 (0.71, 1.04)

  SAEs

RRR = 1 (0.61, 1.64)

RRR = 1.38 (0.40, 4.84)

RRR = 1.38 (0.37, 5.17)

  Discontinuation due to AEs

RRR = 1 (0.55, 1.80)

RRR = 1.04 (0.36, 3.00)

RRR = 1.04 (0.37, 2.89)

  Death

NA

NA

NA

  Time to relapse

ROR = 1.25 (0.03, 60.54)

ROR = 0.17 (0.003, 8.75)

ROR = 0.14 (0.06, 0.30)

  YMRS

NA

NA

NA

  CGI-S

NA

ROM = 0 (− 0.32, 0.32)

NA

  TEAEs

RRR = 0.95 (0.79, 1.15)

RRR = 0.90 (0.76, 1.07)

RRR = 0.95 (0.74, 1.21)

  SAEs

RRR = 2.54 (0.81, 7.98)

RRR = 1.13 (0.62, 2.05)

RRR = 0.44 (0.13, 1.47)

  Discontinuation due to AEs

RRR = 0.88 (0.24, 3.20)

RRR = 0.96 (0.47, 1.99)

RRR = 1.09 (0.34, 3.45)

  Death

NA

NA

NA