Fig. 1
Heatmap of standardized β coefficients for all investigated biomarkers and global, as well as sectoral, circumpapillary retinal nerve fiber layer thickness (cpRNFLT). Separate multivariable linear regression analyses were carried out for each of the biomarkers (independent variable) and the respective sectoral or global cpRNFLT (dependent variable). All multivariable models were adjusted for age, sex, and scanning circle radius. The false-positive discovery rate method was applied to correct p values for multiple comparisons. If the linear regression models did not show an overall significance (indicating that the standardized β is not valid in this sector), a white (empty) square is depicted. For all significant sectors, strength as assessed by standardized β, as well as the direction, of the associations are color-coded. Thus, positive (in red/warmer colors) and negative (in blue/cooler colors) associations are shaded based on the respective standardized β coefficients. Abbreviations: ALAT, alanine aminotransferase; AP, alkaline phosphatase; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ASAT, aspartate aminotransferase; BMI, body mass index; CKD, chronic kidney disease; DBP, diastolic blood pressure; eGFRCys, cystatin C-based estimated glomerular filtration rate; GGT, gamma-glutamyltransferase; HbA1c, glycated hemoglobin A1c; HDL, high-density lipoprotein; hsCRP, high-sensitivity C-reactive protein; IL, interleukin; LDL, low-density lipoprotein; Lp(a), lipoprotein(a); SBP, systolic blood pressure; TG, triglycerides; WHR, waist-to-hip ratio. Optic nerve head sectors: N, nasal sector; NI, infero-nasal sector; NS, supero-nasal sector; T, temporal sector; TI, infero-temporal sector; TS, supero-temporal sector; G, global (mean overall)