Fig. 2

Age-varying effects of the frailty index (FI) on dementia in dizygotic (DZ) and monozygotic (MZ) twin pairs in the within-pair sample I. Age refers to the age at FI assessment. The standard interaction model (a) represents the Cox model adjusted for sex, age at FI measurement, years of education, tobacco use, and interaction terms between FI and zygosity and FI and age at FI measurement. The within-pair interaction model (b) additionally controls for familial factors. The dashed line represents the age-varying estimates in DZ twins and the solid line in MZ twins