Table 3 Diagnostic accuracy of the CD8 T+ cell response and IFN-γ ELISPOT
From: Activated gut-homing CD8+ T cells for coeliac disease diagnosis on a gluten-free diet
Parameter | Total | Subset assayed for both tests | |
|---|---|---|---|
CD8+ response | CD8+ response | IFN-γ ELISPOT | |
AUC (95% CI) | 0.978 (0.953–1.003)† | 0.982 (0.9345–1.028) | 0.889 (0.747–1.031) |
Optimal cut-off | 0.006% | 0.005% | 28.35 |
Sensitivity | 96.67 (82.78–99.92) | 88.89 (51.75–99.72) | 66.67 (29.93–92.51) |
Specificity | 95.0 (86.08–98.96) | 100.00 (73.54–100.00) | 91.67 (61.52–99.79) |
Positive LR | 19.33 (6.40–58.37) | – | 8.0 (1.16–55.26) |
Negative LR | 0.04 (0.01–0.24) | 0.11 (0.02–0.71) | 0.36 (0.14–0.93) |