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Table 3 Diagnostic accuracy of the CD8 T+ cell response and IFN-γ ELISPOT

From: Activated gut-homing CD8+ T cells for coeliac disease diagnosis on a gluten-free diet

Parameter Total Subset assayed for both tests
CD8+ response CD8+ response IFN-γ ELISPOT
AUC (95% CI) 0.978 (0.953–1.003)† 0.982 (0.9345–1.028) 0.889 (0.747–1.031)
Optimal cut-off 0.006% 0.005% 28.35
Sensitivity 96.67 (82.78–99.92) 88.89 (51.75–99.72) 66.67 (29.93–92.51)
Specificity 95.0 (86.08–98.96) 100.00 (73.54–100.00) 91.67 (61.52–99.79)
Positive LR 19.33 (6.40–58.37) 8.0 (1.16–55.26)
Negative LR 0.04 (0.01–0.24) 0.11 (0.02–0.71) 0.36 (0.14–0.93)
  1. Abbreviations: AUC, area under the curve; LR, likelihood ratio considering 1% of coeliac disease prevalence