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Fig. 1 | BMC Medicine

Fig. 1

From: Higher thyrotropin leads to unfavorable lipid profile and somewhat higher cardiovascular disease risk: evidence from multi-cohort Mendelian randomization and metabolomic profiling

Fig. 1

First stage associations between standardized TSH and fT4 within the reference range and 161 Nightingale platform metabolomic markers (N = 9353). Point estimates represent the standardized change in metabolomic marker concentration per standard deviation change in TSH, adjusted for age, sex, body mass index, and smoking. Red bars indicate positive associations; blue bars indicate negative associations. Hollow effect estimates were not statistically significant after correction for multiple testing (p value < 1.34 × 10−3). (1) Extreme large VLDL. (2) Very large VLDL. (3) Large VLDL. (4) Medium VLDL. (5) Small VLDL. (6) Very small VLDL. (7) IDL. (8) Large LDL. (9) Medium LDL. (10) Small LDL. (11) Very large HDL. (12) Large HDL. (13) Medium HDL. (14) Small HDL. (15) Lipoprotein particle size. (16) Cholesterol. (17) Glycerides and phospholipids. (18) Apolipoproteins. (19) Fatty acids. (20) Glycolysis-related metabolites. (21) Amino acids. (22) Branched-chain amino acids. (23) Aromatic amino acids. (24) Ketone bodies. (25) Fluid balance. (26) Inflammation. HDL, high-density lipoprotein; LDL, low-density lipoprotein; VLDL, very-low density lipoprotein

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BMC Medicine

ISSN: 1741-7015

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