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Table 1 Population characteristics of biochemically euthyroid individuals in included cohorts (n = 9432)

From: Higher thyrotropin leads to unfavorable lipid profile and somewhat higher cardiovascular disease risk: evidence from multi-cohort Mendelian randomization and metabolomic profiling

  500 FG GARP LLS NESDA PROSPER RS
N = 362 N = 230 N = 419 N = 2467 N = 4513 N = 1441
Age in years (median (IQR)) 23.0 (21.0–26.0) 59.8 (55.1–65.5) 65.7 (61.8–70.4) 43.0 (30.0–53.0) 75.4 (72.9–78.3) 68.9 (65.2–73.3)
Women 200 (55.2) 181 (78.7) 202 (48.2) 1594 (64.6) 2195 (48.6) 773 (53.6)
Current smoker 47 (13.1)a 38 (16.5) 51 (12.2)c 984 (39.9) 1231 (27.3)g 204 (14.2)h
BMI (median (IQR)) 22.3 (20.8–24.2)b 26.0 (24.0–29.0) 26.3 (24.2–28.6)d 24.6 (22.0–28.0)f 26.2 (23.8–28.9)g 26.4 (24.2–29.0)
TSH (median (IQR)) 2.09 (1.59–2.79) 1.76 (1.27–2.34) 2.13 (1.54–2.89) 2.07 (1.47–2.80) 1.73 (1.22–2.44) 1.76 (1.27–2.51)
fT4 (mean (SD)) 16.4 (2.1) 15.8 (1.8) 15.6 (1.9) 15.6 (2.0) 15.6 (1.9) 15.7 (1.8)
History of diabetes mellitus 0 (0.0) 3 (1.3) 20 (6.0)e 103 (4.2) 471 (10.4) 149 (10.4)i
Lipid-lowering medication use 0 (0.0) 8 (3.5) 55 (16.6)e 184 (7.5) 2248 (49.8) 199 (14.7)j
History of thyroid disease 0 (0.0) N.A. N.A. 62 (2.5) N.A. 111 (7.7)
Thyroid medication use 0 (0.0) 3 (1.3) 7 (2.1)e 34 (1.4) 113 (2.5) 28 (1.9)
Medication use influencing the thyroid gland 0 (0.0) N.A. 1 (0.3)e 3 (0.1) 12 (0.3) N.A.
  1. Results are shown as n (%) unless indicated otherwise. Abbreviations: 500 FG 500 Functional Genomics Study, GARP the Genetics, Arthrosis and Progression study, LLS the Leiden Longevity Study, NESDA the Netherlands Study of Depression and Anxiety, PROSPER PROspective Study of Pravastatin in the Elderly at Risk, RS the Rotterdam Study, BMI body mass index, TSH thyroid stimulating hormone, fT4 free thyroxin, N.A. not available
  2. aInformation on 360 individuals
  3. bInformation on 356 individuals
  4. cInformation on 410 individuals
  5. dInformation on 407 individuals
  6. eInformation on 331 individuals
  7. fInformation on 2465 individuals
  8. gInformation on 4511 individuals
  9. hInformation on 1435 individuals
  10. iInformation on 1438 individuals
  11. jInformation on 1352 individuals