Fig. 2
From: IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis
Identified loci associate with CA HIV-1 DNA. A Manhattan plot of QTL mapping analysis for CA HIV-1 DNA with CA HIV-1 RNA as one of the covariables. One genome-wide significant locus was identified on the short arm of chromosome 11 with leading SNP rs2613996 at the threshold of P < 5 × 10−8. B Box plot of CA HIV-1 DNA for each genotype of rs2613996. The association p value is 9.72 × 10−10 and the rs2613996-A allele contributes to CA HIV-1 DNA positively. C LocusZooom plot of the top SNP of QTL mapping analysis for CA HIV-1 DNA. Every dot in the figures represents a SNP at a threshold of P < 0.01. The top SNP was colored in purple and shaped by a diamond marker. The color of the dots indicates its LD R2 value to the top SNP