Fig. 4

The 5mC clusters and 5mC score correlated with predictors of ICB response in the TCGA-BLCA cohort. A The differences in the expression of 22 immune checkpoints between 5mC clusters. B, C The differences in the enrichment scores of positive ICB response-related signatures and the TIS between 5mC clusters. D The correlations between the 5mC score and TIS. E The lower left part indicates the correlations between the 5mC score and the enrichment scores of positive ICB response-related signatures; the upper right part shows the correlations between the 5mC score and the expression of 22 immune checkpoints. F The difference in mRNA expression of hyperprogression-associated genes between the 5mC score groups. The asterisks indicate a statistically significant p value calculated using the Mann-Whitney U or t-test (*P < 0.05; **P < 0.01; ***P < 0.001). G The difference in copy number variation patterns of hyperprogression-associated genes between the 5mC score groups. The p value was calculated with the Fisher t-test