Table 2 P-values for associations between metabolites and selecteda variables
Metabolite | Variable | Discovery | Validation | ||
|---|---|---|---|---|---|
P-value | minP P-value | P-value | Bonf. P-value | ||
Arginineb | - | - | - | - | - |
Asparagine | BMI | 1.4E−19 | 1.4E−19 | 9.3E−07 | 5.6E−06 |
Waist circumference | 4.8E−16 | 4.8E−16 | 9.9E−05 | 6.0E−04 | |
Hip circumference | 2.2E−13 | 2.2E−13 | 3.7E−03 | 2.2E−02 | |
Waist/hip ratio | 1.3E−05 | 1.0E−03 | 8.2E−03 | 4.9E−02 | |
Fiber intake | 1.3E−03 | 3.9E−02 | 1.5E−01 | 8.9E−01 | |
WCRF/AICR score | 8.3E−04 | 2.4E−02 | 5.0E−01 | 1.0E+00 | |
C2 | Age at blood collection | 8.6E−04 | 2.6E−02 | 2.3E−04 | 1.1E−03 |
Alcohol consumption at recruitment | 2.8E−04 | 8.0E−03 | 2.0E−01 | 1.0E+00 | |
Alcohol consumption (lifetime) | 8.6E−04 | 2.6E−02 | 3.5E−01 | 1.0E+00 | |
Carbohydrate intake | 3.8E−05 | 1.0E−03 | 3.0E−01 | 1.0E+00 | |
Total sugar intake | 2.1E−04 | 6.0E−03 | 1.1E−01 | 5.5E−01 | |
PC aa C36:3 | Age at blood collection | 1.0E−03 | 4.3E−02 | 1.2E−01 | 2.4E−01 |
BMI | 8.9E−04 | 3.6E−02 | 6.7E−02 | 1.3E−01 | |
PC ae C34:2 | Smoking status | 1.2E−04 | 1.0E−03 | 7.5E−01 | 1.0E+00 |
Smoking status and intensity | 2.0E−04 | 3.0E−03 | 8.4E−01 | 1.0E+00 | |
BMI | 5.7E−10 | 45.7E−10 | 6.6E−05 | 7.9E−04 | |
Waist circumference | 2.6E−14 | 2.6E−14 | 3.0E−07 | 3.6E−06 | |
Hip circumference | 4.3E−05 | 4.3E−05 | 2.2E−02 | 2.6E−01 | |
Waist/hip ratio | 5.0E−12 | 5.0E−12 | 3.3E−07 | 3.9E−06 | |
Carbohydrate intake | 4.3E−06 | 4.3E−06 | 4.2E−02 | 5.0E−01 | |
Total sugar intake | 1.4E−03 | 3.2E−02 | 9.8E−01 | 1.0E+00 | |
Total fat intake | 2.2E−09 | 2.2E−09 | 1.4E−04 | 1.7E−03 | |
Fatty acids, total saturated intake | 6.8E−10 | 6.8E−10 | 8.7E−07 | 1.0E−05 | |
Fatty acids, total monounsaturated intake | 1.5E−04 | 1.0E−03 | 1.2E−01 | 1.0E+00 | |
Modified Mediterranean diet score | 5.1E−04 | 1.5E−02 | 9.5E−03 | 1.1E−01 | |
PC ae C36:2 | Smoking status | 2.1E−04 | 6.0E−03 | 6.1E−01 | 1.0E+00 |
Smoking status and intensity | 2.4E−04 | 8.0E−03 | 9.0E−01 | 1.0E+00 | |
Alcohol consumption at recruitment | 4.4E−08 | 4.4E−08 | 1.4E−04 | 1.7E−03 | |
Alcohol consumption (lifetime) | 1.3E−06 | 1.3E−06 | 6.8E−04 | 8.1E−03 | |
BMI | 4.4E−13 | 4.4E−13 | 7.0E−09 | 8.4E−08 | |
Waist circumference | 2.1E−19 | 2.1E−19 | 1.8E−12 | 2.2E−11 | |
Hip circumference | 1.1E−07 | 1.1E−07 | 7.7E−05 | 9.3E−04 | |
Waist/hip ratio | 9.1E−15 | 9.1E−15 | 7.0E−10 | 8.4E−09 | |
Total fat intake | 1.4E−11 | 1.4E−11 | 2.1E−05 | 2.5E−04 | |
Fatty acids, total saturated intake | 2.2E−17 | 2.2E−17 | 1.6E−10 | 1.9E−09 | |
Healthy Lifestyle Index | 2.8E−05 | 2.0E−03 | 2.3E−04 | 2.8E−03 | |
WCRF/AICR score | 3.9E−05 | 2.0E−03 | 8.1E−05 | 9.7E−04 | |
PC ae C36:3 | Smoking status | 3.8E−04 | 7.0E−03 | 8.1E−01 | 1.0E+00 |
Smoking status and intensity | 1.4E−03 | 2.8E−02 | 8.6E−01 | 1.0E+00 | |
BMI | 1.9E−07 | 1.9E−07 | 2.2E−03 | 2.7E−02 | |
Waist circumference | 7.2E−12 | 7.2E−12 | 7.3E−05 | 8.8E−04 | |
Hip circumference | 4.7E−04 | 8.0E−03 | 6.8E−02 | 8.1E−01 | |
Waist/hip ratio | 1.5E−10 | 1.5E−10 | 8.2E−05 | 9.8E−04 | |
Carbohydrate intake | 1.9E−04 | 5.0E−03 | 2.2E−01 | 1.0E+00 | |
Total fat intake | 8.5E−08 | 8.5E−08 | 4.1E−03 | 4.9E−02 | |
Fatty acids, total saturated intake | 1.5E−06 | 1.5E−06 | 1.6E−03 | 2.0E−02 | |
Fatty acids, total monounsaturated intake | 2.8E−05 | 2.8E−05 | 5.0E−02 | 6.0E−01 | |
Fatty acids, total trans intake | 1.4E−04 | 3.0E−03 | 2.1E−01 | 1.0E+00 | |
Modified Mediterranean diet score | 3.0E−04 | 6.0E−03 | 5.6E−02 | 6.7E−01 | |
PC ae C38:2 | Alcohol consumption at recruitment | 3.4E−04 | 2.4E−02 | 1.2E−02 | 9.9E−02 |
BMI | 6.2E−11 | 6.2E−11 | 1.9E−09 | 1.5E−08 | |
Waist circumference | 1.6E−13 | 1.6E−13 | 2.5E−11 | 2.0E−10 | |
Hip circumference | 7.6E−08 | 7.6E−08 | 1.2E−06 | 9.6E−06 | |
Waist/hip ratio | 1.1E−07 | 1.1E−07 | 3.6E−06 | 2.9E−05 | |
Total fat intake | 2.5E−04 | 1.7E−02 | 9.2E−03 | 7.3E−02 | |
Fatty acids, total saturated intake | 1.7E−06 | 1.7E−06 | 1.2E−04 | 1.0E−03 | |
Fatty acids, total trans-polyenoic intake | 1.2E−03 | 4.9E−02 | 6.3E−01 | 1.0E+00 | |