Fig. 1

A Estimated genetic correlation of 14 psychiatric disorders with the LDSC method. The color on the top triangle indicates the magnitude of the genetic correlation; the significance of genetic correlation in − log10(P value) is shown on the bottom triangle, with significant genetic correlations after Bonferroni correction marked with an asterisk. B Cluster analysis based on the estimated genetic correlation matrix produced from cross-trait LDSC for the 14 psychiatric disorders. C Number of pleiotropic genes (FDR < 0.05) discovered by PLACO based on de-correlated Z-statistics for the 14 psychiatric disorders