Fig. 1

Associations of obesity genetic risk and obesity lifestyle risk index with clinically measured BMI with effect modification by comorbidity in the Mass General Brigham Biobank. A Associations of the obesity PRS with clinically measured BMI in all 33,511 patients and associations stratified by lowest and highest morbidity based on the Charlson Comorbidity Index (10-yr survival probability). Effect estimates are derived from a multivariable linear regression model for BMI adjusted for age, sex, genotyping array, and 5 PCs of ancestry per SD of the PRS. B Association of the obesity lifestyle risk index with clinically measured BMI in all 17,040 patients and associations stratified by lowest and highest morbidity. Effect estimates are derived from a multivariable linear regression model for BMI adjusted for age and sex per SD of the obesity lifestyle risk index. Abbreviations: polygenic risk score (PRS), principal components (PCs), standard deviation (SD)