Fig. 4

Phenome-wide association results for the obesity PRS (n =33,511). A Manhattan plot showing phenome-wide associations between the obesity PRS and 675 disease outcomes grouped by their broad disease groups on the x-axis and the -log₁₀P value of the association on the y-axis. The horizontal red line represents the Bonferroni corrected P value cut-off (P value =1.49 × 10⁻⁴). Each disease outcome is represented by either an upward or downward triangle indicating a positive or negative association, respectively. B Pie chart summarizing distribution of significant PheWAS findings across disease groups. Abbreviations: phenome-wide association study (PheWAS), polygenic risk score (PRS)